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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #31

    Treatment of pressure ulcers with autologous bone marrow nuclear cells in patients wi

    Treatment of pressure ulcers with autologous bone marrow nuclear cells in patients with spinal cord injury.

    Sarasúa JG, López SP, Viejo MA, Basterrechea MP, Rodr?*guez AF, Gutiérrez AF, Gala JG, Menéndez YM, Augusto DE, Arias AP, Hernández JO.
    Servicio de Cirug?*a Plástica, Hospital Universitario Central de Asturias, Oviedo, Spain.

    Pressure ulcers are especially difficult to treat in patients with spinal cord injury (SCI) and recurrence rates are high. Prompted by encouraging results obtained using bone marrow stem cells to treat several diseases including chronic wounds, this study examines the use of autologous stem cells from bone marrow to promote the healing of pressure ulcers in patients with SCI.

    To obtain preliminary data on the use of bone marrow mononuclear cells (BM-MNCs) to treat pressure ulcers in terms of clinical outcome, procedure safety, and treatment time.


  2. #32

    Stem Cell Treatment for Spinal Cord Injuries: The New Frontier

    Stem Cell Treatment for Spinal Cord Injuries: The New Frontier
    Posted: Jul 12, 2011 |Comments: 0 |
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    Although the hard bones of the spinal column protect the soft tissues of the spinal cord, vertebrae can still be broken or dislocated in a variety of ways and cause traumatic injury to the spinal cord. Spinal cord injuries vary in their severity, but almost inevitably lead to various forms of compromised functionality as the spinal cord is in effect the main pathway for information to travel around the human body. Precisely what body functions are impaired by the injury will depend on the area of the spine that has been damaged and the extent to which the spine has been affected. Although serious impacts such as falls and motor vehicle accidents account for many spinal cord injuries, tumors growing close to the column can also damage sensitive nerve tissue and have the same effects.

    For decades scientists have been working to try and find a way to remedy the various ailments that spinal cord injuries can bring, but with limited success. However, in recent years a pioneering

    What are Stem Cells and Stem Cell Treatments?

    Stem cells are found in all multi cellular organisms and are characterized by their ability to differentiate into a diverse range of specialized cells when they divide and renew themselves. They are remarkable for their ability to regenerate themselves into almost any other human cell. Their use in the treatment of various diseases and conditions, from Leukemia to Multiple Sclerosis, is now becoming more common. Depending on the condition, stem cells can be transplanted into the patient to help renew and regenerate previously damaged cells, giving patients renewed hope when, before, no reliable treatment existed.

    This principle is now being applied to the treatment of spinal cord injuries using stem cells, and in instances where the patient has not experienced a complete spinal cord injury, i.e. a complete severing of the spinal cord leading to a loss of function below the 'neurological' level. There has been great success in helping patients recover greater sensory and physiological ability.

    Spinal Cord Injury: How Stem Cell Treatment Works

    When there is trauma to the spinal cord, myelopathy (damage to the fibres that carry messages to and from the brain) has occurred. These 'myelinated fibre tracts' are the focus of stem cell treatment, and are the nerve cells that the treatment helps to regenerate. The procedure usually follows three phases and usually requires no longer than a period of around five weeks in medical care for monitoring:

    Phase one involves the harvesting of stem cells. The cells are extracted from a fetus's umbilical cord. They are then put through a process whereby they are isolated and purified before they are finally cultured to be suitable for clinical use.

    Read more:
    Under Creative Commons License: Attribution No Derivatives

  3. #33

    Axon Regrowth with UC San Diego Prof. Binhai Zheng

    Jack - 6/24/2011 5:02:21 PM
    Axon Regrowth with UC San Diego Prof. Binhai Zheng
    Axon Regrowth UC San DIego -- VIdeo Link

    Text of interview:

    “Our lab studied the mechanism of axon regeneration after spinal cord injury.

    We're trying to figure out why axons, the connections between the nerve cells, cannot regenerate after injury such as to the spinal cord or the brain.

    In this study we look at the, the role of 3 major myelin derived growth inhibitors in spinal cord regeneration.

    The 3 molecules are Nogo, MAG, OMgp – they're made by the central nervous system['s] myelin. And we tried to determine whether deletion of 3 inhibitors can lead to enhancement of axon regeneration using experimental injury models in mice.

    What we have learned in this from these experiments are that are following spinal cord injury in these mice axons do not regenerate more than normal – more than wild-type animals. Indicating that the 3 molecules alone cannot explain the failure of axon regeneration after the central nervous system injury.

    There is another form of axonal growth after injury. It's called axonal sprouting. This is the less well studied.

    Axonal sprouting refers to the growth of the uninjured axons as a compensatory mechanism to lost connections after injury. And we found that in these mutants axonal sprouting is enhanced.


  4. #34
    InVivo Therapeutics Congratulates Robert S. Langer as the Recipient of the American Chemical Society’s Priestley Medal
    Award Goes to Chemical Engineer for the First Time in 65 Years

    July 18, 2011 06:03 AM Eastern Daylight Time
    CAMBRIDGE, Mass.--(EON: Enhanced Online News)--InVivo Therapeutics (OTCBB: NVIV) congratulates Robert S. Langer, Sc.D., InVivo co-founder and member of the company’s scientific advisory board, for his selection as the recipient of the American Chemical Society’s (ACS) illustrious Priestley Medal for his distinguished services to chemistry. The Priestly Medal is the highest honor bestowed by the ACS, the world’s largest scientific society. Dr. Langer is the first chemical engineer to win the Priestley Medal in 65 years.

    “Dr. Langer and I co-founded InVivo almost six years ago to create revolutionary treatments for spinal cord injury, but his inventions have become true platform technologies with the potential to affect many unmet medical conditions,” enthused Frank Reynolds, CEO of InVivo Therapeutics. Reynolds adds, “There is no one more deserving of this prestigious achievement.”

    About InVivo Therapeutics


  5. #35
    The Cancer Drug Taxol May Help Spinal Cord Injury Patients
    by John Demas on 07/18/11 at 11:18 am
    Posted in: Spinal Cord Injuries, Spinal Injury News

    Mon, Jul 18, 2011

    Medical researchers keep searching for new ways to help spinal cord injury (SCI) patients regenerate healthy nerve cells so they can achieve higher levels of rehabilitation. At present, most SCI patients must fight regeneration problems caused by scar tissue that increases the barrier between severed nerve cells and an internal cellular process that directly blocks the regrowth of nerve cells.

    Possible Advantages of Prescribing Taxol to SCI Patients
    Recently, scientists working at four worldwide universities and research institutes managed to show that the cancer drug Taxol may help minimize the two nerve cell regeneration issues referenced above. Frank Bradke and his research team at the Max Planck Institute of Neurobiology in Martinsried carefully studied the central nervous system (CNS) nerve cells, trying to determine how they prevent the regrowth of cells after they’ve been damaged. One of the researchers said, “We try to provoke the cells to ignore the stop signs so that they [can] regrow.”

    Currently, researchers are focusing in on the healthy CNS nerve cells’ microtubules (the protein tubes existing in the tips of the nerve cells) that stabilize them and actually aid in “pushing the cell end[s] forward.” It’s this important, latter process that doesn’t seem to be occurring in damaged CNS cells.



  6. #36
    Local support group inspires spinal cord injury victims
    Man inspires people withspinal cord injuries.
    By Josh Brown

    Updated 01:45 a.m., Tuesday, July 19, 2011

    When an 18-wheeler accident left Magui Dunn with a spinal cord injury, she and her husband, Charles Dunn, wanted to find a support group for victims like her. What they did not expect to find, however, was for one man to be all the inspiration they needed.

    Chris Salas started Rolling Inspiration last January after years of “just surviving.” He, like Magui Dunn, was in a car accident 14 years ago that left him with a similar injury, rendering him without the use of his legs and various muscles in his midsection and arms.

    “It was tough at first,” he said. “I spent a lot of time feeling sorry for myself and doing nothing. I went through this phase of wanting to die, and then I didn't want to die.”

    Salas began volunteering for the transportation system at the South Presa Community Center, where he went for rehab and counseling after his accident. One day he was asked to talk to a new spinal-cord injury patient, and Rolling Inspiration was founded.

    “The counselor here would keep calling me to talk to people, so I figured I must be doing something right,” Salas said. “It wasn't so much what the patient got from talking to me so much as the feeling I got talking to them. It kind of inspired me to do it more.”

    Read more:

  7. #37

    Nanomedicine's health hope

    Nanomedicine's health hope

    (Nanowerk News) New nanotechnology-based treatments, including nerve tissue engineering that draws on the limb-regrowing ability of the axolotl, and techniques for targeted attacks on ovarian and lung cancer, were discussed at a major nanomedicine conference in Sydney last week.

    Treatments for cancer, tissue regeneration and disease detection were presented at the Sydney 2011 International Nanomedicine Conference, organised by the University of New South Wales and held at the Crowne Plaza Hotel, Coogee, from Thursday, July 14 to Saturday, July 16.
    More than 50 researchers from academia and industry, including former Australian of the Year Professor Ian Frazer, are presenting at the conference, the largest of its kind in Australia.
    Conference co-chair Professor Tom Davis said the conference, the first sponsored by the new Australian Centre for Nanomedicine at UNSW, was a vital forum for researchers, surgeons and clinicians to discuss latest developments in a field with the potential to revolutionise medicine.


  8. #38
    Quote Originally Posted by paolocipolla View Post
    I agree, each article posted should have its own thread for comments/discussion IMO
    I suspect that "the discussion" is what this thread is supposed to discourage.

  9. #39
    Spinal cord injury cure statement

    check here:

  10. #40

    Never thought it was a good idea from the start, now I'm extra sure it's not.

    Quote Originally Posted by paolocipolla View Post
    I agree, each article posted should have its own thread for comments/discussion IMO

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