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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #201
    Quote Originally Posted by kivi66 View Post
    east dragon, may I ask you to translate what is said there, were or wern't mentioned human-related perspectives.
    the vedio is about ips cure sci.
    Japan:iPS cells cure spinal cord damage
    Tuesday,September 27,

    A research group at a Japanese university says it has successfully used iPS cells to cure damaged spinal cords in mice.

    iPS cells, or induced pluripotent stem cells, have the potential to develop into a variety of tissues or organs.

    The group, led by Professor Hideyuki Okano and lecturer Masaya Nakamura at Keio University, used human iPS cells to treat mice partially paralyzed due to spinal injuries.

    They developed iPS cells into nerve cells and transplanted them into the spinal cords of 31 mice 9 days after they suffered the injuries. All mice showed improved mobility functions, and all were able to walk within 4 weeks.

  2. #202
    Quote Originally Posted by kivi66 View Post
    east dragon, may I ask you to translate what is said there, were or wern't mentioned human-related perspectives.
    needn't translate the vedio, it talked about ips cell cure sci,you read the 194# reply.
    Last edited by east dragon; 09-29-2011 at 11:58 AM.

  3. #203
    The Smallest Revolution: Five Recent Breakthroughs in Nanomedicine
    By Julian Taub | September 30, 2011

    Spinal Cord Repair:

    Accidents occur every year that leave individuals paralyzed and wheelchair-bound for life. When a spine is injured, a cyst can form, blocking the nervous tissue from regenerating. The nerves below the break are then cut off from the rest of the nervous system and atrophy. One of the most famous examples is the late actor Christopher Reeve. Many see stem cells as the solution to spine rehabilitation, but two researchers in Milan have utilized another approach.

    Fabrizio Gelain and Angelo Vescovi constructed nanotubes filled with self-assembling peptides to act as support for the damaged area and mimic the structure of the spine. They tested the procedure on rats and inserted the nanotubes into their broken spines where cysts where forming. After six months, they observed that the cysts were replaced by newly formed cells that included neurons, blood vessels, and bone cells. There were also neurons inside the nanotubes where the peptides originally were. Once the area recovered, the tubes would biodegrade and be eaten by microorganisms.

    Tests on the rats’ motor skills showed that their legs and back motor movements improved and they didn’t have to drag their back legs around anymore. They also responded better to electrophysical stimuli than a control group of rats that were not given nanotubes.

    Gelain is the vice-director of the Center of Nanoscience and Tissue Engineering in Milan. His work centers on developing nanomaterials to repair nerve tissue in victims of spinal cord injuries and strokes. He was a visiting professor at MIT and is an editor at the journals PLoS One and Frontiers in nanotechnology.

    Vescovi, on the other hand, is one of the leading stem cell researchers in Italy and is interested in the regulation of cell growth. His focus is on neural stem cells in the brain and how to use them to treat disorders. He is the director of the Italian Consortium of Stem Cell Research and worked as the stem cell consultant for the Pontifical Academy of Life at the Vatican.

    These innovations I’ve mentioned are just the beginning of how nanotechnology can change our quality of life. Its combined fields are so vast that different disciplines are intertwining and making unpredictable discoveries all the time. Searching nanotechnology online, more often than not I learn about a new breakthrough each day. The question then becomes: What does this all mean? Where is nanotechnology taking us? I don’t think anyone knows at this point, but I’m sure looking forward to the journey.


  4. #204
    Firefighter Revisits Site Of Freak Accident
    Man Defies Odds, Walks After Spinal Cord Injury

    POSTED: Friday, September 30, 2011
    UPDATED: 7:56 pm EDT September 30, 2011

    HOLLYWOOD, Fla. -- A Hollywood firefighter whose spinal cord was injured in a skimboarding accident on Hollywood Beach one year ago has defied the odds.

    Doctors said Derek Avilez would never walk again and would always have to use a ventilator, but one year after the Sept. 30, 2010, accident, he is breathing on his own and has stood up for the first time.

    Avilez, his wife and their three children returned to the beach Friday afternoon for the first time since the accident nearly killed him.

    "I was out of my mind a year ago today, so it just feels good for all five of us to be together," said Avilez's wife, Priscilla. "We were always at the beach, having a good time."


  5. #205
    Neural Linkage Between Motivation and Motor Functional Recovery Through Rehabilitative Training
    Friday, September 30, 2011
    Comments (0)
    Source: National Institute for Physiological Sciences
    Date: September 29, 2011

    An effective recovery has been observed in individuls with stoke or spinal cord injury who have strong vitality and motivation to rehabilitate in clinical practice. However, it was not really clear how motivation facilitates functional recovery in brain science. The joint research team consisting of Associate Professor Yukio NISHIMURA, and Professor Tadashi ISA from the National Institute for Physiological Sciences, Dr. Hirotaka ONOE, Team Leader in the Functional Probe Research Laboratory of RIKEN, the Center for Molecular Imaging Science, and also Dr. Hideo TSUKADA, Manager of PET Center, Hamamatsu Photonics K.K., Central Research Laboratory, revealed that the more motor function recovery progresses, the stronger the functional connectivity between the brain region which regulates motivation, and in the brain regions involved in the motor learning and functional recovery. This occurs through rehabilitative training of macaque monkeys after the spinal cord injuries. read....

  6. #206
    Yoga won't help me walk again. But it has allowed me to 'feel' my legs for the first time in years
    The mention of this ancient exercise system may conjure images incense-filled rooms, but its principles can offer practical benefits to the disabled

    Tim Rushby-Smith, Monday 26 September 2011 16.00 EDT

    have never tried yoga, so I arrived for a class at Triyoga in Chelsea feeling pretty intimidated. My inner cynic expected sinewy people standing on their heads in a fug of incense, but instead I find a large white room scattered with purple mats, foam bricks, blankets and other participants. I choose a space and sit on a mat on the floor.

    When our teacher, Matthew Sanford, arrives he lays a calming hand on my shoulder and in a soft American voice describes me as sporty and determined to the point of bloodymindedness. He recognises this, because I am on the floor with my wheelchair parked next to me – and we are both paraplegic.

    Sanford was just 13 when his family's car hit a patch of ice and slid down an embankment. His mother and brother survived, but his father and sister were both killed. Asleep at the time of the accident, he suffered a broken neck and back, among other injuries. He was in a coma for three days.


  7. #207
    Restoring Function After Spinal Cord Injury With Nerve Transplant: The New Frontier Featured
    Written by Laura Miller | September 22, 2011

    As of yet, scientists and researchers have not been able to completely reverse the damage caused by spinal cord injury, but a core group of experts in this fast-moving field have been making advances with therapies that can return function and make life easier for SCI patients. On Nov. 5, the Institute for Advanced Reconstruction at The Plastic Surgery Center in Shrewsbury, N.J., will be hosting a symposium for medical professionals to discuss advancement in treatment for SCI patients.
    "At the Institute for Advanced Reconstruction, we do things like nerve transplant, re-intubation of the diaphragm for ventilator-dependent patients and therapies to help spinal cord injury patients regain function," says Andrew Elkwood, MD, chairman and founder of The Institute for the Treatment of Paralysis, Jersey Shore Medical Center, N.J., where the symposium will take place. "We deal with everything from nerves to torso and diaphragm issues. We see SCI patients and stroke patients, which means the patients we see crossover with the orthopedic patient population."

    Several surgeons from the Institute for Advanced Reconstruction will be speaking at the seminar, along with Wise Young, MD, a surgeon at NYU Langone Medical Center and director of W.M. Keck Center for Collaborative Neurosciences at Rutgers University, and renowned Chinese surgeon Shaocheng Zhang, MD, professor and chief surgeon in the department of orthopedics at Changhai Hospital in Shanghai. Dr. Zhang uses a unique technique for nerve transplantation, which he will continue to share with American surgeons upon his visit, his first to this country.

    Nerve transplantation
    The nerve transplantation technique Dr. Zhang performs includes multiple procedures to reroute peripheral nerves and restore function for SCI patients. Surgeons connect the rerouted nerves to a different nerve through multiple arrangements. For example, a common procedure includes rerouting an intercostal nerve from the spinal cord around each rib to the sternum before reaching the target nerve site below the injured level of the spine. In cases where the intercostal nerve is not long enough to reach the target nerve, a sural nerve segment can be attached.

    Dr. Zhang has also experienced success rerouting the nerves from the damaged site to other peripheral nerves, such as the ulnar nerve, when the injury site is above the thoracic area where intercostal nerves originate. This technique has been able to restore function for patients with virtually any level of injury: for high-level injury sites, the surgeon can connect functional peripheral nerves above the injury site to nearby dysfunctional nerves below the injury site.

    "We're looking forward to meeting with Dr. Zhang and learning from him," says Dr. Elkwood. "It's really exciting to have him visit us. We're hoping to collaborate with him — we already do many of the things he does, but we want to do collaborative studies."

    Dr. Elkwood and his colleagues also hope to make a trip to China in the future to collaborate with Dr. Zhang and learn more about the surgical technique.

    What the evidence says
    Part of the reason why more surgeons in the United States don't perform nerve transplantation or take on Dr. Zhang's techniques is because the western country has stricter regulations than the eastern country. For better or for worse, these regulations make it hard to bring new products and procedures to the U.S. market that could potentially be very beneficial to patients.



  8. #208
    Prof helps spinal injury with stem cell treatment
    By Love Patel

    A procedure to help eliminate the need for major surgery for patients with spinal cord injuries is being developed by a research group that includes two UH engineering professors.

    The treatment, which involves injecting a solution that contains adult stem cells and nanoparticles into the patients’ spinal cord, would also help with recovery.

    “The nanoparticles will be used to help move the stem cells in the proper direction, and I am working on the fundamentals of this process,” said Li Sun, assistant professor of mechanical engineering.

    After the solution is injected, a magnetic field will expose the magnetic properties of the nanoparticles and turn them into an anchor that guides the stem cells.

    The nanoparticles gain polarity, so they attach to each other along the line where the magnetic field is present.

    This way, the stem cells align properly to reconnect the separated part of the spinal cord.


  9. #209
    EuroSpine: Press Conference Invitation / Spine Specialists Meet at the International EuroSpine 2011 Congress in Milan

    MILAN, Italy, Oct. 4, 2011 /CNW/ - The European congress for spine therapy, surgery and orthopaedics will take place in Milan, Italy from 19-21 October and will attract numerous medical experts and industry specialists from around the globe. Thousands of participants will exchange their profound knowledge about latest research results, technologies and methods of treatment.

    EuroSpine - The Spine Society of Europe, endorses the DECADE OF ACTION FOR ROAD SAFETY campaign ( initiated by the United Nations and coordinated by the World Health Organization (WHO), launched worldwide in 2011.


  10. #210
    The cure for paralysis?
    Ryan Wallace | Oct 04, 2011 | Comments 0

    In May 2011, UC Irvine opened the doors to the Sue and Bill Gross Stem Cell Research Center, a 100,000 square foot facility that cost nearly $80 million to construct.
    The center ushered in a new future for stem cell research. Being the first major stem cell research facility in Southern California, the scientists here at UC Irvine have already begun to prove the benefits of the research that they are doing here.

    This past week, the research that husband-and-wife world-renowned research team, Brian Cummings and Aileen Anderson, finally came into fruition as the first patient began treatment in the clinical trial for the UC Irvine-developed stem cell therapy. This stem cell therapy utilizes purified neural stem cells to fix damage that has occurred along the vertebral column.

    Ideally, once these neural stem cells are transplanted into the spinal cord they will travel to the specific site of injury and grow into neural tissue cells, repairing serious injuries that may have resulted in the loss of mobility. Cummings and Anderson believe that these cells will grow into new nerve tissue at injured areas.

    The clinical trial’s first patient has already began treatment, a 23-year-old man from Germany, who after a debilitating car accident last April lost the ability to move his legs. The accident left him paralyzed from the waist down, and according to a statement released by StemCells, Inc., produced the neural cells used in the therapy.

    This clinical trial already has international weight, and is taking place at the Balgrist University Hospital in Zurich, Switzerland.

    Although there will be many hurdles to cross in this initial clinical trial, such as testing the efficiency of the treatment and making it through the difficult process, the patient remains hopeful.


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