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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #11
    Cleveland researchers use experimental nerve 'bridge' to restore breathing in rats with spinal cord injuries (video)


    Published: Wednesday, July 13, 2011, 1:00 PM Updated: Wednesday, July 13, 2011, 3:29 PM
    By John Mangels, The Plain Dealer The Plain Dealer

    CLEVELAND, Ohio -- Using tools familiar to any gardener -- a chemical fertilizer and a sort of high-tech trellis -- Cleveland researchers have coaxed skittish nerve fibers to bridge a gap in rats' damaged spinal cords and forge new connections.

    The repairs, though experimental, revived the rats' partially paralyzed diaphragm muscles, restoring normal or near-normal breathing in nine of 11 test animals, the Case Western Reserve University scientists report Thursday in the journal Nature.

    "It's pretty amazing," said CWRU neuroscientist Jerry Silver, who led the research project and described it as the culmination of 30 years of effort. "Our work is one of the most convincing demonstrations [to date] of the return of robust function" after paralysis.

    The CWRU approach blends two nerve-regrowth methods, leveraging the power of each.

    "The experiments are significant in demonstrating that this combination of two repair strategies can work together to enhance recovery in the complex circuitry that controls breathing," spinal cord injury researcher James Fawcett, who heads Britain's Cambridge Centre for Brain Repair at the University of Cambridge, said via email. "This paper from the Silver laboratory shows that a combination treatment can be very successful." Fawcett was not involved in the CWRU project.

    Researchers have tried many techniques over the years to overcome the devastation of spinal cord injuries, which affect 12,000 Americans annually. Progress has been slow, a testament to the human nervous system's complexity.

    Much of that experimental work has focused on re-establishing the ability to walk, a goal that remains unmet. Silver's lab has concentrated instead on the challenges of regaining breathing and bladder control. "Our goal was to target one critical muscle that [paralyzed] people would like back," he said.

    Those two bodily functions are far less complicated than walking in terms of making neurological fixes. The shortest stroll requires a suite of highly coordinated limb and trunk movements involving dozens of muscles; by contrast, breathing and urination basically involve flexing only the diaphragm or the sphincter. Restoring them could boost paralyzed patients' long-term survival and dramatically improve their day-to-day lives.

    read....

    http://www.cleveland.com/science/ind..._use_expe.html

  2. #12
    Picture shows paralyzed player standing
    NewsCore





    --
    Updated Jul 13, 2011 7:10 PM ET

    Rutgers defensive lineman Eric LeGrand Wednesday tweeted photos of himself standing up for the first time since suffering a spinal cord injury that left him paralyzed nine months ago.

    With his mother at his side, LeGrand tweeted a picture of himself standing with assistance, telling his 7,000-plus followers, "Standing up little by little in therapy."


    read....


    http://msn.foxsports.com/collegefoot...ding-up-071311

  3. #13

    Neuralstem Announces Notice of Allowance for Two Additional Neurogenic Compound Paten

    Neuralstem Announces Notice of Allowance for Two Additional Neurogenic Compound Patents


    July 14, 2011 8:02 AM EDT


    ROCKVILLE, Md., July 14, 2011 /PRNewswire/ -- Neuralstem, Inc. (NYSE Amex: CUR) announced that it has received notice of allowance for U.S. Patent Applications 12/939,897 and 12/939,914 entitled: "Compositions to Effect Neuronal Growth." The patents cover three new compounds and include both structure and method claims for inducing neurogenesis and the growth of new neurons, both in-vitro and in-vivo.

    (Logo: http://photos.prnewswire.com/prnh/20061221/DCTH007LOGO )

    Neuralstem's first neurogenic patented compound is currently in a Phase I FDA-approved safety trial in major depressive disorder. The Phase Ia trial, which is in healthy volunteers, is scheduled to be completed in August. The Phase Ib safety trial in depressed patients is expected to commence this fall

    continue...

    http://www.streetinsider.com/Press+R...s/6637484.html

  4. #14
    Senior Member NW-Will's Avatar
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    Congratulations, Dee Manouli. You provide a valuable research and news service for CareCure.
    I have to say though I miss seeing the article headline as a new subject line each time you post a fresh article. Some of the article titles really draw me in. Just saying... Keep up the awesome work.

  5. #15
    Senior Member lynnifer's Avatar
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    Agreed NW.
    Make America Sane Again. lol

    T-11 Flaccid Paraplegic due to TM July 1985 @ age 12

  6. #16
    Quote Originally Posted by NW-Will View Post
    I have to say though I miss seeing the article headline as a new subject line each time you post a fresh article. Some of the article titles really draw me in. Just saying... Keep up the awesome work.
    agreed...

    this will get chaotic

  7. #17

    Smile

    Quote Originally Posted by NW-Will View Post
    I have to say though I miss seeing the article headline as a new subject line each time you post a fresh article. Some of the article titles really draw me in. Just saying... Keep up the awesome work.
    Hi, I want to make you happy guys, and do what is the best way. Thanks all of you for your kind words. When the cure is here we are all going to get together with Dr. Young and have a big happy party. Also we are going to dance the tango because we will be able to do so.

    manouli.

  8. #18

    StemCells, Inc. Initiates World��s First Neural Stem Cell Trial In Spinal Cord Injury

    this must be new one. if ir is not forgive me.

    quote:

    The proposed study will be conducted at the Balgrist University Hospital, in Zurich, which is a private, non-profit institution managed in accordance with economic principles



    StemCells, Inc. Initiates World��s First Neural Stem Cell Trial In Spinal Cord Injury





    StemCells Inc Press Release

    StemCells Inc announced today they are initiating a clinical trial using their fetal derived neural progenitor cells for the treatment of spinal cord injuries. Previously the company had reported that their stem cells, called HuCNS-SC, are capable of differentiating into various neural lineage cells including neurons, oligodendrocytes, and astrocytes. The fact that HuCNS-SC are derived from fetal sources allows them to possess a lower ability to stimulate immune responses, therefore, the cells can be used as an ��off the shelf�� product.
    According to the company ��The Company��s preclinical research has shown that HuCNS-SC cells can be directly transplanted in the central nervous system (CNS) with no sign of tumor formation or adverse effects. Because the transplanted HuCNS-SC cells have been shown to engraft and survive long-term, this suggests the possibility of a durable clinical effect following a single transplantation. StemCells believes that HuCNS-SC cells may have broad therapeutic application for many diseases and disorders of the CNS, and to date has demonstrated human safety data from completed and ongoing studies of these cells in two fatal brain disorders in children.��
    The proposed study will be conducted at the Balgrist University Hospital, in Zurich, which is a private, non-profit institution managed in accordance with economic principles. The clinic has three key areas of expertise: it is a highly specialised centre providing examination, treatment and rehabilitation opportunities to patients with serious musculoskeletal conditions; it is responsible for training future doctors studying at the University of Zurich in orthopaedics and paraplegiology and providing professional training for doctors and medical staff in the domains of orthopaedics, paraplegiology, rheumatology, anaesthesiology and radiology; it is a research centre dedicated to improving quality for healthcare in the future. The number of patients or inclusion/exclusion criteria for the trial was not mentioned in the press release. However a look at clinicaltrials.gov reveals the following:
    The study is a 12 patient Phase I/II trial in which treated patients will also receive immune suppression so that the transplanted cells will not be rejected. The trial has the following inclusion/exclusion criteria:
    Inclusion Criteria:



    read....

    http://www.unistemcells.com/en/news/...1492915952.htm

  9. #19

    Local researchers to partner in 'sensorimotor' project

    Local researchers to partner in 'sensorimotor' project
    Posted: Jul 14, 2011 1:58 PM PDT Updated: Jul 14, 2011 1:58 PM PDT


    SAN DIEGO (CNS) - San Diego State University, Southwestern College in Chula Vista and the San Diego-based life science industry group BIOCOM will be partners in researching the brain's control of body movements, the National Science Foundation announced Thursday.

    The goal of the $18.5 million study will be to translate the findings into improved prosthetics for amputees, sensor-electrode systems that reanimate paralyzed limbs and home-based rehabilitation for spinal cord injuries.

    The project could benefit wounded soldiers, accident victims with spinal cord injuries and those who suffer from cerebral palsy, stroke, Parkinson's disease or age-related neurological disorders.

    "Our ultimate goal is that we want to remotely control a robotic device through neural function, not joysticks," SDSU mechanical engineering Professor Kee Moon said.

    read...

    http://www.cbs8.com/story/15083863/l...imotor-project


    NSF Funds $18.5 Million Effort to Create Mind-Machine Interface
    Released: 7/14/2011 9:00 AM EDT
    Source: University of Washington

    Newswise — The National Science Foundation today announced an $18.5 million grant to establish an Engineering Research Center for Sensorimotor Neural Engineering based at the University of Washington.

    “The center will work on robotic devices that interact with, assist and understand the nervous system,” said director Yoky Matsuoka, a UW associate professor of computer science and engineering. “It will combine advances in robotics, neuroscience, electromechanical devices and computer science to restore or augment the body’s ability for sensation and movement.”

    The center launches this month and will be based in Russell Hall on the UW’s Seattle campus. The grant is for five years of funding, with the possibility of renewal for another five years.

    Partners are the Massachusetts Institute of Technology and San Diego State University. Also partnering are historically minority-serving institutions Spelman College and Morehouse College, both in Atlanta, and Southwestern College in Chula Vista, Calif. International partners are the University of British Columbia and the University of Tokyo.

    continue....

    http://www.newswise.com/articles/nsf...hine-interface
    Last edited by manouli; 07-15-2011 at 07:17 AM.

  10. #20

    Spinal Cord Injury Research

    Spinal Cord Injury Research


    Helping Patients to Walk Again: Nerve Regeneration



    quote:

    "I am optimistic that we will be conducting human clinical trials within ten years," says Dr. Windebank. "This project is so exciting that I can't wait to get into the lab."

    lolol if you cannot wait, why you have to wait 10 years to start?


    Anyway, a lot of good information here....

    please check this out...

    http://discoverysedge.mayo.edu/spina...jury/index.cfm

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