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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #1031
    Neuroscience
    November 19, 2018
    ⦁ Scientists identify novel target for neuron regeneration and functional recovery in spinal cord injury
    November 19, 2018 by Jeremy Walter, Temple University
    Restoring the ability to walk following spinal cord injury requires neurons in the brain to reestablish communication pathways with neurons in the spinal cord. Mature neurons, however, are unable to regenerate their axons to facilitate this process. Now, in new research, scientists at the Lewis Katz School of Medicine at Temple University (LKSOM) show that this limitation may be overcome by targeting liver kinase B1 (LKB1) protein. In mice with spinal cord injury, targeted LKB1 upregulation stimulated long-distance neuron regeneration, leading to gains in functional recovery.
    read....
    https://medicalxpress.com/news/2018-...-recovery.html

  2. #1032
    quote: However, in animals treated long after injury, the therapeutic effects of the enzyme were remarkably better. In as little as one week after treatment in chronically injured rats

    lolo, how 're you like this?


    Researchers restore breathing, partial forelimb function in rats with spinal cord injuries
    Promising results provide hope for humans suffering from chronic paralysis
    Date:
    November 27, 2018
    Source:
    Case Western Reserve University
    Summary:
    Millions of people worldwide are living with chronic spinal cord injuries, with 250,000 to 500,000 new cases each year -- most from vehicle crashes or falls. The most severe spinal cord injuries completely paralyze their victims and more than half impair a person's ability to breathe. Now, a breakthrough study has demonstrated, in animal models of chronic injury, that long-term, devastating effects of spinal cord trauma on breathing and limb function may be reversible.
    read...
    https://www.sciencedaily.com/release...1127131559.htm

  3. #1033
    EXCLUSIVE - The year paralyzed people walked again: Two patients who made history with world-first spinal implants describe the joy of little things like standing to cook breakfast and going to the bathroom
    ⦁ Kelly Thomas, 23, of Homosassa, Florida, was left paralyzed after her truck rolled over in July 2014
    ⦁ Jeff Marquis, 35, of Louisville, Kentucky, suffered a mountain bike accident while he was living in Montana in September 2011
    ⦁ Both are now walking again thanks to a device implanted below the injured area of their spines, which allows the neurons in their legs to connect to their brains
    ⦁ This is coupled with intense physical therapy that retrains the spinal cord to communicate with the brain
    read...
    https://www.dailymail.co.uk/health/a...l-implant.html

  4. #1034
    Microtube-embedded Chondroitinase ABC shows promise for treating spinal cord injuries
    Download PDF Copy
    View Supplier Profile
    Jan 9 2019Reviewed by Kate Anderton, B.Sc.
    AMSBIO, a leading global supplier of Chondroitinase ABC enzyme, reports on the recent publication by Hu et al. of the therapeutic efficacy of microtube-embedded Chondroitinase ABC on a group of dogs with naturally occurring spinal injuries.
    read.....
    https://www.news-medical.net/news/20...-injuries.aspx

  5. #1035
    InVivo Therapeutics Announces Appointment of Richard Christopher as Chief Financial Officer and Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)
    Published: Jan 14, 2019 8:00 a.m. ET
    /press-release/invivo-therapeutics-announces-appointment-of-richard-christopher-as-chief-financial-officer-and-reports-inducement-grant-under-nasdaq-listing-rule-5635c4-2019-01-14/email
    /press-release/invivo-therapeutics-announces-appointment-of-richard-christopher-as-chief-financial-officer-and-reports-inducement-grant-under-nasdaq-listing-rule-5635c4-2019-01-14/print
    InVivo Therapeutics Holdings Corp. NVIV, +0.00% a research and clinical-stage biomaterials and biotechnology company with a focus on treatment of spinal cord injuries (SCIs), today announces the appointment of Richard Christopher as its Chief Financial Officer and Treasurer, effective January 14, 2019.
    read...
    https://www.marketwatch.com/press-re...5c4-2019-01-14

  6. #1036
    Update for its OPC1 Phase 1/2a Clinical Trial in Severe Spinal Cord Injury
    PRESS RELEASE GlobeNewswire Jan. 24, 2019, 07:00 AM

    FREMONT, Calif., Jan. 24, 2019 (GLOBE NEWSWIRE) -- Asterias Biotherapeutics, Inc. (NYSE American: AST), a biotechnology company dedicated to developing cell-based therapeutics to treat neurological conditions associated with demyelination and cellular immunotherapies to treat cancer, today provided top-line 12 month data from the Company’s Phase 1/2a SCiStar study designed to evaluate the safety and potential efficacy of OPC1 in the treatment of severe cervical spinal cord injury (SCI). All 25 subjects from the SCiStar study have now completed 12-months of follow-up as part of the study’s protocol. The Company also held a Type B meeting with the Food and Drug Administration (FDA) late last year where FDA agreed with the Company’s plan to initiate a randomized, controlled Phase 2 study to further evaluate the safety and efficacy of OPC1.
    more...
    https://markets.businessinsider.com/...ury-1027892664

  7. #1037
    A real-life Superman: Christopher Reeve's daughter says his foundation has raised $138M for spinal injury research, helping develop a promising new technique that has seen the paralyzed walk again
    ⦁ Alexandra Reeve Givens says the Christopher and Dana Reeve Foundation has raised $138million for scientific research into paralysis
    ⦁ The Superman actor looked forward to seeing new developments such as the new technique that has helped paralyzed people stand and take steps again
    ⦁ Reeve's spinal cord was injured in a 1995 horse riding fall. He died in 2004
    ⦁ She remembered her dad helping others before and after his accident
    read...
    https://www.dailymail.co.uk/news/art...yzed-walk.html

  8. #1038
    Quote Originally Posted by manouli View Post
    A real-life Superman: Christopher Reeve's daughter says his foundation has raised $138M for spinal injury research, helping develop a promising new technique that has seen the paralyzed walk again
    ⦁ Alexandra Reeve Givens says the Christopher and Dana Reeve Foundation has raised $138million for scientific research into paralysis
    ⦁ The Superman actor looked forward to seeing new developments such as the new technique that has helped paralyzed people stand and take steps again
    ⦁ Reeve's spinal cord was injured in a 1995 horse riding fall. He died in 2004
    ⦁ She remembered her dad helping others before and after his accident
    read...
    https://www.dailymail.co.uk/news/art...yzed-walk.html
    Gov't approves test using iPS cells to treat spinal cord injuries
    Feb. 19 06:45 am JST
    9 Comments
    By Christophe Gateau
    TOKYO
    A team of Japanese researchers will carry out an unprecedented trial using a kind of stem cell to try to treat debilitating spinal cord injuries, the specialists said on Monday.
    The team at Tokyo's Keio University has received government approval for a trial using so-called induced Pluripotent Stem (iPS) cells -- which have the potential to develop into any cell in the body -- to treat patients with serious spinal cord injuries.
    The trial, expected to begin later this year, will initially focus on four patients who suffered their injuries just 14 to 28 days beforehand, the university said.
    more...
    https://japantoday.com/category/feat...ith-stem-cells

  9. #1039
    SpineX Names Scientific Advisory Board to Guide Development of Non-Invasive Medical Devices for Neuromodulation of the Spine
    \l "\l "\l "https://plus.google.com/share?url=http://globenewswire.com/news-release/2019/02/26/1742433/0/en/SpineX-Names-Scientific-Advisory-Board-to-Guide-Development-of-Non-Invasive-Medical-Devices-for-Neuromodulation-of-the-Spine.htmlEmail Print Friendly Share
    February 26, 2019 08:15 ET | Source: SpineX
    LOS ANGELES, Feb. 26, 2019 (GLOBE NEWSWIRE) -- SpineX, a developer of non-invasive medical devices to address a broad range of medical conditions through the neuromodulation of the spinal cord to restore function lost to injury and disease, named a group of leading scientists in the field of neuroscience and medicine to serve on its scientific advisory board.
    “As SpineX seeks to address a range of medical issues through the neuromodulation devices it is developing, these renowned scientists will help guide us with their expertise and knowledge,” said Dr. V. Reggie Edgerton, co-founder and Chief Scientific Officer of SpineX. “Their insights will help accelerate the translation of our pioneering science into products that benefit patients with conditions ranging from incontinence to paralysis.”
    more...
    https://globenewswire.com/news-relea...the-Spine.html

  10. #1040
    Senior Member
    Join Date
    Apr 2016
    Location
    Cincinnati, Ohio, USA
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    2,561
    $138 million since the foundation was started is pretty bad news from where I stand. Curing SCI isn't a millions of dollars project, it's a billions of dollars project. Just getting epidural stim commercialized will take the companies working on it about $35 million from what I've heard. That's AFTER the research phase and that's not a cure, but just estim.

    Imagine if we could have HALF of the $5.7 billion wall project for SCI. SCI costs the US taxpayer something north of $20 billion / year so curing it with a few billion bucks is a net savings.
    But that's just rational thought instead of politics, so it won't happen.
    T3 complete since Sept 2015.

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