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Thread: There's never been a better time to be a paralyzed rat:

  1. #1

    There's never been a better time to be a paralyzed rat:

    http://m.digitaljournal.com/pr/4560957

    """Animals treated with P7C3 exhibited improved neuron and oligodendrocyte survival, locomotor function, tissue repair, and myelination when compared to untreated animals."""

  2. #2
    As is often the case, the headlines here are misleading.

    I've attempted to attach an image of Figure 1 from the actual paper.

    You'll see that the rats were given this compound 1 day after injury, in the acute stage.

    You'll also see that the rats that did not receive the experimental compound - the control rats - recovered walking to a score of about 12 on the BBB locomotor score, which ranges from 0-21. The rats that did receive the compound achieved a score of about 15/21 on the same scale.

    In practical terms, this means that the rats who got injuries and a placebo treatment achieved "uncoordinated stepping", while the rats who received the experimental compound barely achieved "forelimb and hindlimb coordination." This link provides an overview of the BBB scale:
    https://pages.jh.edu/SCI/characterization/bbb.shtml

    All of the images of the injury site are similar in nature, with the control rats still having some spared neural tissue at the injury site - the experimental rats just had more tissue. While these results were statistically significant, it's nothing that hasn't been seen before.
    Attached Images Attached Images  

  3. #3
    Quote Originally Posted by tomsonite View Post
    As is often the case, the headlines here are misleading.

    I've attempted to attach an image of Figure 1 from the actual paper.

    You'll see that the rats were given this compound 1 day after injury, in the acute stage.

    You'll also see that the rats that did not receive the experimental compound - the control rats - recovered walking to a score of about 12 on the BBB locomotor score, which ranges from 0-21. The rats that did receive the compound achieved a score of about 15/21 on the same scale.

    In practical terms, this means that the rats who got injuries and a placebo treatment achieved "uncoordinated stepping", while the rats who received the experimental compound barely achieved "forelimb and hindlimb coordination." This link provides an overview of the BBB scale:
    https://pages.jh.edu/SCI/characterization/bbb.shtml

    All of the images of the injury site are similar in nature, with the control rats still having some spared neural tissue at the injury site - the experimental rats just had more tissue. While these results were statistically significant, it's nothing that hasn't been seen before.

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