Spinal Cord Injury Articles Posted by Manouli

[manouli]

Public Release: 26-Jun-2018
Inflammation discovery opens window to better rehabilitation possibilities
Findings could have significant impact on how spinal cord injuries are treated in the future
University of Alberta
Inflammation plays a key role in improving the ability to relearn motor skills lost as a result of spinal cord injuries, such as grasping objects, new University of Alberta research shows.
U of A spinal cord researchers Karim Fouad, a Canada Research Chair in the Faculty of Rehabilitation Medicine, and Abel Torres Esp?n studied inflammation and rehabilitation training in rodents and discovered that creating a mild inflammatory response improved a rat's ability to relearn how to pick up pellets months following a spinal cord injury.
read....
https://www.eurekalert.org/pub_relea...-ido062618.php

[manouli]

BioArctic Receives Regulatory Approval in Finland for a Clinical Study in Patients With Complete Spinal Cord Injury

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STOCKHOLM, July 10, 2018 /PRNewswire/ -- BioArctic AB (publ) (Nasdaq Stockholm: BIOA B) announced today that the company has received approval by Fimea, the Finnish Medicines Agency, and Valvira, the Finnish authority for medical device, as well as the local ethics committee for inclusion of Finnish patients in BioArctic's ongoing clinical Phase 1/2 study with SC0806. The candidate product is a combination of a medical device (implant) and a medicinal product (FGF1) for patients with complete spinal cord injury. This approval means that BioArctic has received approvals in all the countries planned to participate in the study, i.e. Sweden, Estonia, Norway and now Finland.
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https://www.prnewswire.com/news-rele...300678409.html

[manouli]

Heriot-Watt study says mind matters for spinal patients


A study carried out at Heriot-Watt University found benefits from working with a patient's mind as well as body.
The Edinburgh researchers said a change in the way people view their surroundings after injury can make it harder to carry out everyday tasks.
Some patients, they said, might regain some movement in their legs.
The study found patients were often unaware of how far they could reach.
This affected tasks such as picking up a cup, feeding themselves and carrying out basic self-care.
The research found that, even if a patient's upper limbs are uninjured, they struggle with spatial judgement.
The work brought together researchers in Italy, Switzerland and the UK.
more...
https://www.bbc.co.uk/news/uk-scotla...-fife-44838109

[manouli]

Plant compounds found to activate cells used in transplants for spinal cord repair

Natural compounds derived from Australian plants have been found to stimulate cells that are useful for transplantation to repair spinal cord injuries.
The results of this research have recently been published in Scientific Reports by a team of scientists based at the Griffith Institute for Drug Discovery (GRIDD) and Menzies Health Institute Queensland (MHIQ).
GRIDD Senior Researcher Associate Professor James St John said the two compounds were sourced from the Australian desert plant Eremophila microtheca by the natural product chemist Associate Professor Rohan Davis, who heads NatureBank which is a vast resource of Australian natural products used for drug discovery.
“Identifying natural products that stimulate the body’s natural repair mechanisms is an exciting area of research, and has great potential for the discovery of new drugs,” Associate Professor Davis said.
“The current collaboration between GRIDD and MHIQ, while still only in its infancy, is gaining traction, and the recent findings are very encouraging.”
read...
https://app.secure.griffith.edu.au/n...l-cord-repair/

[manouli]

Asterias Biotherapeutics : Provides 12 Month Cohort 3 and 4 Update for its AST-OPC1 Phase 1/2a Clinical Trial in Severe Spinal Cord Injury
08/01/2018 | 10:28am CEST

Asterias Biotherapeutics, Inc. (NYSE American:AST), a biotechnology company dedicated to developing cell-based therapeutics to treat neurological conditions associated with demyelination and cellular immunotherapies to treat cancer, today provided additional data from the Companys ongoing Phase 1/2a SCiStar study designed to evaluate the safety and potential efficacy of AST-OPC1 in the treatment of severe cervical spinal cord injury.
The SCiStar study is an open-label, single-arm trial testing three escalating doses of AST-OPC1 in 25 subjects with subacute motor complete (AIS-A or AIS-B) cervical (C-4 to C-7) spinal cord injury. These individuals have lost essentially all movement below their injury site and experience severe paralysis of the upper and lower limbs.
more...
http://www.4-traders.com/ASTERIAS-BI...lini-27033682/

[manouli]

New study offers hope of recovery from spinal cord injury
July 25, 2018, Tel Aviv University
Spinal cord injury or damage causes permanent changes in strength, sensation and other body functions. Hope of recuperation is slim to none. Now a new Tel Aviv University study finds the intravenous injection of a potent enzyme, just hours after an accident, has the potential to diminish a cascade of pathological events responsible for neuronal death, such as inflammation and scarring.
The study was conducted by Dr. Angela Ruban of TAU's Sackler Faculty of Medicine and Dr. Yona Goldshmit of TAU's Sackler Faculty of Medicine and the Australian Regenerative Medicine Institute, Monash University. It was published in May in the Journal of Neurotrauma.
"Primary mechanical damage to spinal cord tissue kills a certain amount of neuronal cells. But there's secondary damage due to the release of excess glutamates, which are responsible for additional functional disability," Dr. Goldshmit says. "The main idea is to reduce the secondary damage as soon as possible—to block the body's natural reaction to spinal cord trauma. This is the role of the enzyme injection we devised."
"When this new treatment will be available to paramedics, the consequences of injuries could be dramatically reduced," Dr. Ruban says.
read...
https://medicalxpress.com/news/2018-...rd-injury.html

[manouli]

New 3D-printed device could help treat spinal cord injuries
August 9, 2018

Engineers and medical researchers at the University of Minnesota have teamed up to create a groundbreaking 3D-printed device that could someday help patients with long-term spinal cord injuries regain some function.
A 3D-printed guide, made of silicone, serves as a platform for specialized cells that are then 3D printed on top of it. The guide would be surgically implanted into the injured area of the spinal cord where it would serve as a type of “bridge” between living nerve cells above and below the area of injury. The hope is that this would help patients alleviate pain as well as regain some functions like control of muscles, bowel and bladder.
more...
https://twin-cities.umn.edu/news-eve...-cord-injuries

[manouli]

NervGen Pharma Announces Granting of US Patent for Breakthrough Nerve Regeneration Technology
Posted by: Nasdaq NewsFeed in Top News 2 days ago
VANCOUVER, British Columbia, Aug. 10, 2018 (GLOBE NEWSWIRE) — NervGen Pharma Corp. (“NervGen”), a regenerative medicine company dedicated to creating innovative solutions for the treatment of nerve damage, announces the issuance by the U.S. Patent and Trademark Office of a patent central to the development and commercialization of protein tyrosine phosphatase sigma (PTPs) targeted therapies for spinal cord injury and nerve damage.

more...
https://forextv.com/top-news/nervgen...on-technology/

[Silvio GS]

When I just look at the amount of promising breakthroughs our dear Manouli have posted about in this thread all these years... it makes me think like really?... what’s going on? We still have nothing

[Moe]

When I just look at the amount of promising breakthroughs our dear Manouli have posted about in this thread all these years... it makes me think like really?... what?s going on? We still have nothing

At this point, research to me has lots in common with politics: All talk, no action.... keep the hype up to get the stock money flowin'... let the funds/grants/donations benefit everybody involved except for the injured...

"wouldn't it be nice if things were all-action and no talk?"