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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #971
    Adipose-derived mesenchymal stem cells combined with fibrin matrix influences restoration of motor functions
    Download PDF Copy
    April 24, 2018
    The research team used model spinal cord injuries in rats for their purposes. As a result, it was found out that therapy by adipose-derived mesenchymal stem cells combined with fibrin matrix influences the restoration of motor functions. It also decreases the area of pathological cavities and reduces astroglial activation.
    read..
    https://www.news-medical.net/news/20...functions.aspx

  2. #972
    Spinal cord injury research: Bonus benefit to activity-based training
    January 31, 2018 by Betty Coffman, University of Louisville
    Credit: CC0 Public Domain
    Activity-based training has resulted in unexpected benefits for individuals with severe spinal cord injury (SCI). Researchers in the Kentucky Spinal Cord Injury Research Center (KSCIRC) at the University of Louisville have discovered that the training, designed to help individuals with SCI improve motor function, also leads to improved bladder and bowel function and increased sexual desire.

    read....
    https://medicalxpress.com/news/2018-...s-benefit.html

  3. #973
    Experimental drug restores some bladder function after spinal cord injury, study finds
    Mice given test compound show marked improvements
    By: Misti Crane
    Published on June 04, 2018
    COLUMBUS, Ohio – An experimental drug that blocks abnormal neural communication after spinal cord injury could one day be the key to improving quality of life by improving bladder function, new research suggests.
    Researchers at The Ohio State University tested the drug – which is currently available only for research – to gauge its potential to improve bladder function after spinal cord injury in mice and saw promising results.
    The experimental drug (LM11A-31) appears to help by blocking the dual activity of pro-nerve growth factor (proNGF) and a receptor called p75. ProNGF is known to be secreted from the cell after nerve injury.
    read...
    https://news.osu.edu/news/2018/06/04...spinal-injury/

  4. #974
    chronic spinal cord injuries! Yahoo!


    Possible new treatment for spinal cord injuries identified in animal studies
    June 11, 2018 by Steve Tally, Purdue University



    An experimental drug has shown promise as a potential therapy for spinal cord injuries in animal studies.
    The compound, 4-aminopyridine-3-methanol, works in a similar way as a drug previously developed at Purdue, 4-aminopyridine (4-AP), which has been approved by the U.S. Food and Drug Administration to treat multiple sclerosis.
    Dr. Riyi Shi, professor in the Department of Basic Medical Sciences, College of Veterinary Medicine and Weldon School of Biomedical Engineering, who was involved in the development of both drugs, compared the two compounds in both cell cultures and animal models.
    "For the first time, 4-aminopyridine-3-methanol is shown to restore function in chronic spinal cord injuries," he says. "It also reduces neuropathic pain to a greater degree than 4-AP.
    more...
    https://medicalxpress.com/news/2018-...es-animal.html

  5. #975
    Quote Originally Posted by manouli View Post
    chronic spinal cord injuries! Yahoo!


    Possible new treatment for spinal cord injuries identified in animal studies
    June 11, 2018 by Steve Tally, Purdue University



    An experimental drug has shown promise as a potential therapy for spinal cord injuries in animal studies.
    The compound, 4-aminopyridine-3-methanol, works in a similar way as a drug previously developed at Purdue, 4-aminopyridine (4-AP), which has been approved by the U.S. Food and Drug Administration to treat multiple sclerosis.
    Dr. Riyi Shi, professor in the Department of Basic Medical Sciences, College of Veterinary Medicine and Weldon School of Biomedical Engineering, who was involved in the development of both drugs, compared the two compounds in both cell cultures and animal models.
    "For the first time, 4-aminopyridine-3-methanol is shown to restore function in chronic spinal cord injuries," he says. "It also reduces neuropathic pain to a greater degree than 4-AP.
    more...
    https://medicalxpress.com/news/2018-...es-animal.html
    Awesome news, I'll need to read more!

  6. #976
    Senior Member
    Join Date
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    Houston, Texas
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    Quote Originally Posted by tomsonite View Post
    Awesome news, I'll need to read more!
    https://www.purdue.edu/newsroom/rele...l-studies.html

  7. #977
    So is 4-aminopyridine-3-methanol available for sci or not?
    "I'm manic as hell-
    But I'm goin' strong-
    Left my meds on the sink again-
    My head will be racing by lunchtime"

    <----Scott Weiland---->

  8. #978
    New Gene Treatment Helps Rats Regain Use of Paws After Spinal Injury
    After proving successful with rats, new gene therapy could be a step closer to restoring mobility in humans who've suffered severe spinal injuries.
    Rats are giving new hope to patients struggling with spinal cord injuries. Researchers from the King's College London managed to successfully restore rats' paw usage, thanks to a gene therapy treatment.
    The new treatment mended the rats' damaged spin nerves by first dissolving the scar tissue. This broke down the barrier between nerves that often form after a spinal column injury, thus giving the nerves a better chance of healing.
    Those nerve connections were improved by the treatment also producing an important enzyme called chondroitinase. That enzyme not only breaks down the tissue, but it also allows the nerves to reconnect easily with each other.
    read...
    https://interestingengineering.com/n...-spinal-injury

  9. #979
    Local man first in drug trial for spinal cord injuries


    Published: 06/26/18 04:49 pm EDT
    Updated: 06/26/18 06:36 pm EDT
    COLUMBUS, Ohio
    A terrible bike accident caused local triathlete, Allen Frye, to suffer a severe spinal cord injury.
    He's the first in the world to try a medication to lessen the damage done and he is making remarkable progress at OSU Wexner Medical Center.

    https://www.10tv.com/article/local-m...-cord-injuries

  10. #980
    RXi shares in $1.8M grant to treat spinal cord injuries
    Marlborough drugmaker RXi Pharmaceuticals is set to receive nearly $250,000 in grant funds for a collaboration with Cambridge-based BioAxone BioSciences.
    continue...

    http://www.wbjournal.com/article/201...WS01/180709994

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