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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #1051
    Science
    JNCASR’s molecule improves recovery after spinal cord injury

    Spinal cord injury can now be repaired using a small molecule (TTK21) synthesised by a team led by Tapas Kumar Kundu from the Molecular Biology and Genetics Unit at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, a study has found. The small molecule tested both on mice and rat models promoted regeneration and growth of new sensory and motor axons leading to recovery of sensory and motor functions in the animals with spinal cord injury.
    more...
    https://www.thehindu.com/sci-tech/sc...le26830296.ece

  2. #1052
    Senior Member lunasicc42's Avatar
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    Quote Originally Posted by manouli View Post
    Science
    JNCASR’s molecule improves recovery after spinal cord injury

    Spinal cord injury can now be repaired using a small molecule (TTK21) synthesised by a team led by Tapas Kumar Kundu from the Molecular Biology and Genetics Unit at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru, a study has found. The small molecule tested both on mice and rat models promoted regeneration and growth of new sensory and motor axons leading to recovery of sensory and motor functions in the animals with spinal cord injury.
    more...
    https://www.thehindu.com/sci-tech/sc...le26830296.ece

    This study is on acute injury rats
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  3. #1053
    REPROCELL and Q Therapeutics to co-develop clinical grade iGRP for treatment of various CNS disorders. REPROCELL will manufacture clinical grade iGRP at the cGMP suite to conduct preclinical safety/efficacy studies and clinical trials.

    REPROCELL Inc. today announced that it has established the current good manufacturing practice (cGMP) cell processing suite at Life Innovation Center (LIC) in Tonomachi area in Kawasaki city for production of iPS Cell-derived Glial Progenitors (iGRP) for treatment of CNS disorders. The suite has been designed to support Clinical Trials of cell therapy products.
    REPROCELL has been jointly developing iGRP with Q Therapeutics Inc. (Utah, USA) for treatment of various intractable CNS diseases and injuries. The target indications of iGRP include Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS) Transverse Myelitis (TM), Spinal Cord Injuries (SCI) and Stroke. REPROCELL will manufacture clinical grade iGRP at the suite to conduct preclinical safety/efficacy studies and clinical trials.
    In addition, REPROCELL plans to manufacture and store clinical grade iPS Cell Bank as raw material for iPS Cell-derived cellular products at the suite according to US/EU/Japan regulations and guidelines and plans to support academia and industry for manufacturing materials for animal studies and clinical trials.
    read....
    https://www.prweb.com/releases/repro...eb16308451.htm

  4. #1054
    Kessler Foundation receives $1 million gift to study groundbreaking treatments for spinal cord injury
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    Reviewed by James Ives, M.Psych. (Editor)Jun 7 2019
    Tim Reynolds, co-founder of the Wall Street firm Jane Street Capital, and his wife, Caroline, made a $1 million gift to Kessler Foundation to launch groundbreaking research at the Foundation's new Center for Spinal Stimulation. The Reynolds gave this gift in recognition of the compassionate care delivered by Barbara Benevento, MD, of Kessler Institute for Rehabilitation and to the work of the spinal cord research team. Mr. Reynolds sustained a spinal cord injury in 2000 as a passenger in a motor vehicle accident, and underwent rehabilitation at Kessler Institute.
    more....
    https://www.news-medical.net/news/20...rd-injury.aspx

  5. #1055
    ReNetX Bio, Inc. Announces U.S. FDA Authorization to Proceed for IND Application to Treat Patients with Chronic Spinal Cord Injury
    Published: Jun 19, 2019
    NEW HAVEN, Conn., June 19, 2019 /PRNewswire/ -- ReNetX Bio, Inc., a leading biotechnology company committed to reversing disease and damage for patients suffering from central nervous system disorders, has announced that the U.S. Food and Drug Administration (FDA) has allowed the Company's Investigational New Drug (IND) application for its lead drug candidate, fusion protein AXER-204.

    read...
    https://www.biospace.com/article/rel...l-cord-injury/

  6. #1056
    https://medicalxpress.com/archive/09-07-2019/
    July 9, 2019
    Bias erodes translational value in animal spinal cord injury studies
    by Eileen Scahill, The Ohio State University
    An analysis led by researchers from The Ohio State University College of Medicine at The Ohio State University Wexner Medical Center found that bias in the design and reporting of spinal cord injury (SCI) studies in animals results in overestimation of the effectiveness of a potential treatment to prevent infections in human patients with SCI.
    read...
    https://medicalxpress.com/news/2019-...inal-cord.html

  7. #1057
    injection of nanoparticles for spinal cord injuries
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    By Dr. Ananya Mandal, MDJul 11 2019
    Researchers from the University of Michigan used nanopaticles injection to prevent the immune cells of the body from impairing the healing of injured brain and spinal cord. They call this an “EpiPen” or emergency rescue drug for the brain and spinal cord when they suffer trauma.


    https://www.news-medical.net/news/20...-injuries.aspx

  8. #1058
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    Quote Originally Posted by manouli View Post
    https://medicalxpress.com/archive/09-07-2019/
    July 9, 2019
    Bias erodes translational value in animal spinal cord injury studies
    by Eileen Scahill, The Ohio State University
    An analysis led by researchers from The Ohio State University College of Medicine at The Ohio State University Wexner Medical Center found that bias in the design and reporting of spinal cord injury (SCI) studies in animals results in overestimation of the effectiveness of a potential treatment to prevent infections in human patients with SCI.
    read...
    https://medicalxpress.com/news/2019-...inal-cord.html

    This is so f'ing true!
    T3 complete since Sept 2015.

  9. #1059
    Science News
    from research organizations

    Boosting the discovery of new drugs to treat spinal cord injuries using zebrafish
    New platform allows effective drug screening
    Date:
    July 19, 2019
    Source:
    Instituto de Medicina Molecular
    Summary:
    A research team led by Leonor Sa?de, Principal Investigator at Instituto de Medicina Molecular, in partnership with the company Technophage, SA, has designed a simple and efficient platform that uses zebrafish to discover and identify new drugs to treat spinal cord lesions. This study is the proof-of-concept for the use of this zebrafish platform that, combined with drug repurposing, has the potential to accelerate the translation period from the discovery to the clinics.
    more.....
    https://www.sciencedaily.com/release...0719102103.htm

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