Public release date: 11-Jul-2011
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Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair

Neural stem progenitor cell transplantation’s potential to aid spinal cord injury tested




Tampa, Fla. (July. 11, 2011) – A study published in the current issue of Cell Transplantation (20:5) investigating optimal routes for transplanting neural stem/progenitor cells (NS/PCs) in animal models of spinal cord injury (SCI) has demonstrated that intralesional (IL) injection conferred benefits over intravenous injection (IV) and intrathecal (IT) injection. The study, by a team of Keio University (Japan) researchers, is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ .

"Spinal cord injury usually results in severe, paralytic damage because the adult central nervous system has little potential for regeneration after injury," said corresponding author Dr. Masaya Nakamura of the Keio University School of Medicine's Department of Orthopedic Surgery. "With cell transplantation of neural stem/progenitor cells being a promising strategy, our study sought to determine the best method of application for optimal cell survival and subject safety."

For their study, the researchers used a new reporter gene, called "ffLuc," a novel fusion protein, for bioluminesence (BLI) imaging in order to track the transplanted cells via MRI from injection site to spinal cord lesion.

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http://www.eurekalert.org/pub_releas...-nsp071111.php