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Thread: Project Walk initiates a new research project with Children's National Medical Center

  1. #1

    Project Walk initiates a new research project with Children's National Medical Center

    Children's National Medical Center has provided pilot funding for the following project:

    Research Strategy

    The primary aim of this study is to examine effects of various modalities of exercise on alterations in neuroplasticity-related proteins in men and women with SCI. A secondary aim is to examine exercise-induced changes in these proteins across subjects differing in injury level and completeness of injury. Changes in circulating neurotrophic factors in approximately 15-20 individuals with chronic or sub-acute (> 8 weeks post injury) SCI will be measured. All will have a complete or incomplete SCI, and meet the following criteria: C2 or lower injury level, non ventilator-dependent, and physician’s permission to engage in an exercise program. Participants’ sensory and motor function will be assessed via Manual Muscle Testing (0-10 point rating scale for all major muscle groups) and the ASIA scale (rating of motor and sensory function) at baseline. Subjects will complete an exercise session lasting two hours, consisting of 30 minutes of load bearing with passive movement (this will consist of use of a standing frame with a glider attachment), 30 minutes of whole body vibration (WBV), 30 minutes of body weight support treadmill training (BWSTT), and 30 minutes of functional electrical stimulation (FES) leg ergometry. Compliance to exercise will be monitored to ensure that subjects complete all components of training. Blood samples will be obtained pre-exercise (baseline) and after completion of each modality. Circulating concentrations of the following neurotrophins will be measured: BDNF, GDNF , NT-3, IGF-1, prolactin, and cortisol.


    Eric Harness, CSCS
    Founder/President
    Neuro Ex, Inc
    Adaptive Performance and Neuro Recovery

  2. #2
    Quote Originally Posted by Snowman View Post
    Children's National Medical Center has provided pilot funding for the following project:

    Research Strategy

    The primary aim of this study is to examine effects of various modalities of exercise on alterations in neuroplasticity-related proteins in men and women with SCI. A secondary aim is to examine exercise-induced changes in these proteins across subjects differing in injury level and completeness of injury. Changes in circulating neurotrophic factors in approximately 15-20 individuals with chronic or sub-acute (> 8 weeks post injury) SCI will be measured. All will have a complete or incomplete SCI, and meet the following criteria: C2 or lower injury level, non ventilator-dependent, and physician’s permission to engage in an exercise program. Participants’ sensory and motor function will be assessed via Manual Muscle Testing (0-10 point rating scale for all major muscle groups) and the ASIA scale (rating of motor and sensory function) at baseline. Subjects will complete an exercise session lasting two hours, consisting of 30 minutes of load bearing with passive movement (this will consist of use of a standing frame with a glider attachment), 30 minutes of whole body vibration (WBV), 30 minutes of body weight support treadmill training (BWSTT), and 30 minutes of functional electrical stimulation (FES) leg ergometry. Compliance to exercise will be monitored to ensure that subjects complete all components of training. Blood samples will be obtained pre-exercise (baseline) and after completion of each modality. Circulating concentrations of the following neurotrophins will be measured: BDNF, GDNF , NT-3, IGF-1, prolactin, and cortisol.
    This is great news. I look forward to seeing the data when published.

    Keep up the good work Eric.

  3. #3
    FPF

    Thanks for the encouragement!

    The best way to keep track of ongoing research, etc. at Project Walk is to follow the Project Walk Institute blog here. I am trying to do a better job at keeping it updated...


    Eric Harness, CSCS
    Founder/President
    Neuro Ex, Inc
    Adaptive Performance and Neuro Recovery

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