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Thread: Motor Neurons Spared In SMA, ALS and Spinal Cord Injury Models

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    Motor Neurons Spared In SMA, ALS and Spinal Cord Injury Models

    "We've taken a critical step forward in directing stem cell differentiation, and illustrating their ability to spare spinal cord cells from loss after injury or disease. We see a future where we will have the ability to maintain dying motor neurons by delivering motor neuron-specific neurotrophic support.This will be a powerful treatment strategy for diseases characterized by motor neuron loss such as ALS, SMA and spinal cord injury. We are encouraged, and cautiously optimistic."
    Specifically, we transplanted hMNPs into rodent models of SMA (?7SMN), ALS (SOD1 G93A), and spinal cord injury (SCI). The transplanted cells survived and differentiated in all models.

    Read more: http://www.sfgate.com/cgi-bin/articl...#ixzz1MBZjOgWe
    KB

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    This has been coming for a while, nice to see a paper published. GOOOOO Hans!!!!!!

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    Quote Originally Posted by rjames View Post
    This has been coming for a while, nice to see a paper published. GOOOOO Hans!!!!!!
    Do you know if these hMNPs cells are expected to replace already differentiated oligodendrocyte cells in trials? What do hMNPs differentiate into?
    KB

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    Quote Originally Posted by kbailey View Post
    Do you know if these hMNPs cells are expected to replace already differentiated oligodendrocyte cells in trials? What do hMNPs differentiate into?
    I don't know the answer to your question. Try sending Hans a PM.....

  5. #5
    Quote Originally Posted by kbailey View Post
    Do you know if these hMNPs cells are expected to replace already differentiated oligodendrocyte cells in trials? What do hMNPs differentiate into?
    Kbaily, I don't believe the hMNPs would be a replacement.

    Oligodendrocytes are myelinating glial cells found in all regions of the central nervous system. The major function of oligodendrocytes is to form myelin sheaths around axons to ensure the rapid and faithful transmission of electrical signals. During development, oligodendrocytes precursor cells (OPCs) have to go through a series of morphological and molecular changes before they become fully differentiated into mature myelinating oligodendrocytes. The differentiation and myelination processes of oligodendrocytes are tightly controlled by transcription factors.

    http://www.labome.org/grant/r01/ns/t...n-7888164.html



    http://www.plosone.org/article/info%...l.pone.0011852


    Interestingly, hMNP transplantation resulted in survival, differentiation, and site-specific integration of hMNPs distal to the SCI site within ventral horns, but hMNPs near the SCI site reverted to a neuronal progenitor state, suggesting an environmental deficiency for neuronal maturation associated with SCI.
    Last edited by GRAMMY; 05-13-2011 at 11:15 PM.

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