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Thread: 4-ap coming to human phase 3 trials soon!!

  1. #1
    Senior Member
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    4-ap coming to human phase 3 trials soon!!

    Even though many of you think 4-ap is a waste. It is at least a start in getting a therapy or drug to the phase 3 level for chronic MS and SCI.

    After my refill of baclofen pump at RIC here in Chicago, I talked to a few of the uppity ups lol and was told it will be a double blind trial with 50% getting the placebo.

    At RIC you will have to come to the clinic once a week for a certain period and be able to stay for 2-3 hrs. as A c-7 incomplete quad I am signed up for this trial. Hopefully some of you will get involved also.

    It's not the magic bullet we all want but hopefully it can help some sci's with some improvements.



    Ps. Don't ever give up and remember the impossible dream:

    To dream the impossible dream
    To fight the unbeatable foe
    To bear with unbearable sorrow
    To run where the brave dare not go ...

    To right the unrightable wrong
    To be better far than you are
    To try when your arms are too weary
    To reach the unreachable star ...

    This is my quest,
    to follow that star
    No matter how hopeless,
    no matter how far ...

    To be willing to die
    so that honor and justice may live ...

    To be willing to march into hell for a heavenly cause

    And I know - if I'll only be true
    to this glorious quest -
    That my heart
    will lie peaceful and calm
    when I'm laid to my rest.

    And the world will be better for this
    That one man,
    scorned and covered with scars,
    Still strove
    with his last ounce of courage
    To reach the unreachable star ...

    [This message was edited by The Human Cannonball on Mar 21, 2002 at 12:22 PM.]

    [This message was edited by The Human Cannonball on Mar 21, 2002 at 12:55 PM.]

  2. #2
    The Good News: 4-AP is not a waste and will be of some benefit to 20%+ of the chronic SCI population

    The Bad News: 4-AP has been around for 20+ years and is just getting to phase 3 trials. Yikes!

  3. #3

    4-AP Experience

    THC,

    First you quoted my favorite song. Second, I started 4-AP last week and have ramped up to 25 mg so far with the ultimate goal being 40mg. I've noticed a electric hum all through my body and an increase in bowel movements (not good). I've also noticed that my spasms have stopped in my back but continue midly from the butt dowm. I can now control the spasm at will. My heart rate runs too high at times (155/142) but usually calms down after an hour.

    Quadfather,

    The phase III clinical trial is probably Framindine-SR which I've heard is not exactly the same as the 4-AP that is now available. Do a search on Framidine as Dr. Young has explained the differences in the past.

    Deb

  4. #4

    4-AP

    There is some stuff about the marketing of the sustained release form of the drug on the ACORDA website. I saw it last week I think.

  5. #5
    Super Moderator Sue Pendleton's Avatar
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    Oh great THC. You're quoting songs Jim Nabors sang as Gomer Pyle...

  6. #6
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    But Sue, I actually took the lyrics from a frank sinantra web site lol.



    And of course i saw the Man of LaManca(sp?) as a child.

    John

    [This message was edited by The Human Cannonball on Mar 22, 2002 at 09:27 AM.]

  7. #7
    Senior Member
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    The question is folks...is Spinal Cord Injury a "Kobioshi - Maru" scenario (the Star Trek no
    win scenario that Kirk beats by reprogramming the computer")

    not anymore....

    Eric Texley

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