Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons
+ Author Affiliations

aFishberg Department of Neuroscience and
bDepartment of Neurosurgery, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029; and
cGenentech, Inc., South San Francisco, CA 94080
Edited by Mark H. Tuszynski, University of California at San Diego, La Jolla, CA, and accepted by the Editorial Board April 1, 2011 (received for review January 11, 2011)

Axon growth potential is highest in young neurons but diminishes with age, thus becoming a significant obstacle to axonal regeneration after injury in maturity. The mechanism for the decline is incompletely understood, and no effective clinical treatment is available to rekindle innate growth capability.