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Thread: Olfactory ensheathing glial cell transplant treatment of cerebral palsy

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    Olfactory ensheathing glial cell transplant treatment of cerebral palsy

    I attach the reprint which is available from

    Cell Transplantation, Vol. 19, pp. 185–191, 2010 Printed in the USA. All rights reserved. Copyright  2010 Cognizant Comm. Corp.
    0963-6897/10 $90.00 + .00 DOI: 10.3727/096368910X492652 E-ISSN 1555-3892

    Brief Communication

    Intracranial Transplant of Olfactory Ensheathing Cells in Children and Adolescents With Cerebral Palsy: A Randomized Controlled Clinical Trial
    Lin Chen,*â€* Hongyun Huang,*â€* Haitao Xi,*â€* Zihang Xie,* Ruiwen Liu,* Zhao Jiang,* Feng Zhang,* Yancheng Liu,* Di Chen,* Qingmiao Wang,* Hongmei Wang,*â€* Yushui Ren,â€* and Changman Zhouâ€*‡
    *Center for Neurorestoratology, Beijing Rehabilitation Center, Beijing, P.R. China â€*Beijing Hongtianji Neuroscience Academy, Beijing, P.R. China ‡Department of Anatomy and Embryology, Peking University Health Science Center, Beijing, P.R. China

    Successful repair of damage in cerebral palsy (CP) needs effective clinical interventions other than simply symptomatic treatments. To elucidate the feasibility of using olfactory ensheathing cells (OECs) to treat CP in children and adolescents, we conducted a randomized controlled clinical trial (RCT) on 33 patients. The patients were randomly assigned into two groups (treatment group, n = 18; control group, n = 15), and OECs derived from aborted fetal tissue were injected into the bilateral corona radiata in the frontal lobes (a key point for neural network restoration, KPNNR). The Gross Motor Function Measure (GMFM-66) and the Caregiver Questionnaire Scale were used to evaluate the patients’ neurological function and overall health status. Among the 14 patients who completed the 6-month study, six received the cell transplantation and the other eight served as controls. In OEC treatment group, GMFM-66 scores were 26.67 ± 25.33 compared with 19.00 ± 20.00 for the control group. Concurrently, the Caregiver Questionnaire Scale score decreased to 77.83 ± 15.99 in the treatment group in comparison to 138.66 ± 64.06 of the control group. This trial, albeit small in sample size, indicates OEC KPNNR transplantation is effective for functional improvement in children and adolescents with CP, yet without obvious side effects. This small-scale study suggests that the procedure may be a plausible alternative method to treat this not yet curable disorder, and we urge further evaluation with a large-scale RCT.

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