Page 11 of 22 FirstFirst ... 23456789101112131415161718192021 ... LastLast
Results 101 to 110 of 212

Thread: The 4-AP List

  1. #101
    Quote Originally Posted by iamash View Post
    I am a C5 incomplete injury who is taking steps with a walker, 1 year post injury. I asked my doctor if I could try 4-AP. She prescribed 5mg/day, which I took for 2 months now. I asked her today if I could please increase the dose and she was hesitant, stating that the drug was "experimental" and it can interact with the Baclofen that I take (70mg/day) and actually cause more spasms? She reluctantly increased it to 5mg TID. Warned me about using this drug with caution because it can cause seizures and decrease circulation in the lower extremities. Told me to watch for purplish color in my feet or mottling.

    I had originally given her a well written article on this drug along with some prescribing guidelines, but she chose to ignore that information.

    Is this drug worth trying? Will I get any kind of improvements with 15mg/day?
    I don't know where your doctor is getting her information concerning 4-AP but it is not likely that 5 mg per day or even 5 mg three times a day would have much effect. The treatment is also more likely to improve existing sensory and motor function rather than restore where there were none. There is no evidence that it increases spasticity or spasms. I have also not heard of evidence suggesting that it will decrease circulation in the lower extremities. Did it affect your function, spasticity, or spasms?

    In high doses, 4AP may cause seizures in people who have had seizures or a reason for seizures. In the clinical trials, 4-AP was given alongside baclofen but I don't think that there were any adverse reactions. Wise.

  2. #102
    Dr. young what are your thoughts on the Purdue study?
    http://news.uns.purdue.edu/x/2009b/091119ShiSpinal.html
    Last edited by Mike Pell; 01-05-2010 at 07:50 PM. Reason: grammar
    Mike P.

  3. #103
    Quote Originally Posted by Mike Pell View Post
    Dr. young what are your thoughts on the Purdue study?
    http://news.uns.purdue.edu/x/2009b/091119ShiSpinal.html

    I'd like to hear Wise's opinion of this as well

  4. #104
    Senior Member NW-Will's Avatar
    Join Date
    Apr 2008
    Location
    Vancouver WA USA - - Male T4 ASIA B incomplete
    Posts
    1,786
    Does anyone know of any literature online I can show my Doctor, that will persuade him to increase my dosage of 4-ap to 60mg daily?

    I'm currently on 40mg a day with no side effects.

    It seems as though some people are taking 100mg a day.

    4-Aminopyridine (4-AP) Treatment Evaluations

    Thanks.

  5. #105
    100 mg a day is way too high.
    The test of success is not what you do when you are on top. Success is how high you bounce when you hit the bottom
    --General George Patton

    Complex problems need to be solved collectively.
    ––Paul Nussbaum
    usc87.blogspot.com

  6. #106
    Senior Member NW-Will's Avatar
    Join Date
    Apr 2008
    Location
    Vancouver WA USA - - Male T4 ASIA B incomplete
    Posts
    1,786
    Quote Originally Posted by pn View Post
    100 mg a day is way too high.

    source.

  7. #107
    From doctors when I was involved in the long term clinical trials.
    The test of success is not what you do when you are on top. Success is how high you bounce when you hit the bottom
    --General George Patton

    Complex problems need to be solved collectively.
    ––Paul Nussbaum
    usc87.blogspot.com

  8. #108
    My doctor refuses to give me a prescription to take 4ap. He said to await
    the FDA approved version, which I did but came to figure out that it would be another 4 mnths or so until it's available and that it will cost a lot more then the compound version because it will be a name brand drug and considered "off-label".

    I have not tried it yet but wanted to try it just incase it was worth taking longterm. I feel it makes a lot more sense to try it at $75 as opposed to a few hundred. If I give the compound a couple of mnths and find it beneficial then I'd be open to switching to the controlled version my doctor prefers. Despite me stating my reasons I was denied. Last time I checked it was my body and i have offered to sign forms waving liability. I really do not want to go through the cost or time and effort to see a new doctor. Any suggestions?

  9. #109
    Senior Member mr_coffee's Avatar
    Join Date
    Mar 2005
    Location
    San Francisco, CA
    Posts
    6,030
    Quote Originally Posted by PN View Post
    100 mg a day is way too high.
    jesus, 100mg?

    I literally blacked out and my parents found me passed out on a table when I took two 20mg to close together.

    I weigh like 120lbs. The mg dosage I thought was based off your body weight, thats what they did for me anyways. After that I would take 10mg, 3x a day.
    Injured:10-16-04
    C7/C8, T1 incomplete;


    For stalkers convenience:
    Blog:
    http://www.ordealsonwheels.com/
    Facebook:
    http://www.facebook.com/#!/coryssanchez
    Progress:
    http://photobucket.com/albums/b290/swooty/
    My drawings:
    http://kanvases.com/sites/corysanchez/home

  10. #110
    Cory, I have never heard anyone say that the dosage is based on or off your body weight.
    The test of success is not what you do when you are on top. Success is how high you bounce when you hit the bottom
    --General George Patton

    Complex problems need to be solved collectively.
    ––Paul Nussbaum
    usc87.blogspot.com

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •