I am currently in the end of the third week of the Open Label 4-AP clinical trials at the VA in Long Beach, California. I started at 20 mgs.for the first week and did not notice much of a change and had no side-effects. Second week, I was at 30 mgs a day and I noticed a decrease in spasms and muscle tone. In the third week the dose was increased to 40 mgs and I noticed that my muscle tone and spasms have decreased by 30%. I can, also, put my left hand on top of my head which is something that I could not do before. This coming Tuesday the dose will be increased to 50 mgs and I will report any changes, good or bad.

Just so that there is no confusion: Acorda has called 4-AP Fampridine-SR for the past few years as I have been told.

PN