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Thread: PTEN Study

  1. #11
    Don't get all excited about this, as I said in my earlier post- PTEN is a tumor suppressor! You take it away and you get cancer.
    Here's a couple reviews on what it does in cell cycle regulation

    http://jco.ascopubs.org/content/22/14/2954.full

    Tenets of PTEN tumor suppression

    In relation to my first idea about transiently knocking down PTEN levels... may not work after all.
    Even partial reduction of PTEN levels can lead to cancer

  2. #12
    Quote Originally Posted by dr.zapp View Post
    Don't get all excited about this, as I said in my earlier post- PTEN is a tumor suppressor! You take it away and you get cancer.
    Here's a couple reviews on what it does in cell cycle regulation

    http://jco.ascopubs.org/content/22/14/2954.full

    Tenets of PTEN tumor suppression

    In relation to my first idea about transiently knocking down PTEN levels... may not work after all.
    Even partial reduction of PTEN levels can lead to cancer
    dr. Zapp,

    As I understand knocking down PTEN create a sequence of events, I am not sure how much is known about what really happens. I would think that, maybe, we can somehow bypass the cancer activation and keep just the regeneration, or neutralize the cancer, or something else...
    What is clear is that we can turn on massive regeneration just knocking down PTEN.
    I think once we have a clear map of what happens knocking down PTEN, we may find the final solution.
    In God we trust; all others bring data. - Edwards Deming

  3. #13
    Quote Originally Posted by paolocipolla View Post
    dr. Zapp,

    As I understand knocking down PTEN create a sequence of events, I am not sure how much is known about what really happens. I would think that, maybe, we can somehow bypass the cancer activation and keep just the regeneration, or neutralize the cancer, or something else...
    What is clear is that we can turn on massive regeneration just knocking down PTEN.
    I think once we have a clear map of what happens knocking down PTEN, we may find the final solution.
    The PI3K/AKT/PTEN/mTOR signalling pathway is one of the most studied signalling cascades in cancer. Regeneration and cancer are so similar, the only difference is cancer bypasses the "stop and differentiate" signals... which are precisely those controlled by the PI3K/mTor pathway that PTEN regulates.

  4. #14
    I'm going to be following this group closely now- a good friend just got a postdoc in Dr. He's lab- the group that published this- and is going to be working on the mouse SCI injury project!

  5. #15
    Quote Originally Posted by dr.zapp View Post
    I'm going to be following this group closely now- a good friend just got a postdoc in Dr. He's lab- the group that published this- and is going to be working on the mouse SCI injury project!
    Fantastic! We're fascinated with the PTEN study and would love to hear anything and everything you could offer for us. Super deal!!!!!!
    Congrats to your good friend!

  6. #16
    Dr. Young have you an opinion on this study?

  7. #17
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    Seems to be a great step forward.
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  8. #18
    More details (Wise's comments included) in this thread:

    http://sci.rutgers.edu/forum/showthread.php?t=138809

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