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Thread: PTEN Study

  1. #1
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    PTEN Study

    Here's a great video about the recent work regarding PTEN from our friends at the Reeve-Irvine Research Center
    http://www.vimeo.com/18333473
    Last edited by rjames; 02-16-2011 at 02:59 AM.

  2. #2
    I saw the paper about this, looked very interesting... http://www.ncbi.nlm.nih.gov/pubmed/20694004
    My thoughts on this however, are what are the long term effects of such a treatment? PTEN is a tumor suppressor, it is down-regulated in all sorts of different cancers. It is a main player in cell cycle regulation. In fact, a PTEN conditional knock-out mouse is one we use to study phaeochromocytomas... http://www.ncbi.nlm.nih.gov/pubmed/19142977
    Sure, you may help nerve growth... but get cancer in 5 years. Not saying this is not important research, just that the media hype around it has been curiously absent of the actual role of PTEN in cells.
    However, using RNAi, it would be possible to do transient PTEN knock-down in the CNS... hmmmm.
    Last edited by dr.zapp; 02-16-2011 at 03:23 AM.

  3. #3
    Quote Originally Posted by rjames View Post
    Here's a great video about the recent work regarding PTEN from our friends at the Reeve-Irvine Research Center
    http://www.vimeo.com/18333473
    Fantastic video rjames! Thanks for putting up the link for everyone!
    This is really great!!!

  4. #4
    Quote Originally Posted by rjames View Post
    Here's a great video about the recent work regarding PTEN from our friends at the Reeve-Irvine Research Center
    http://www.vimeo.com/18333473
    Thanks rjames,

    do you know if they have been able to see functional returns associated to the regeneration they have obtained?
    Last edited by paolocipolla; 02-17-2011 at 09:43 PM.
    In God we trust; all others bring data. - Edwards Deming

  5. #5
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    Quote Originally Posted by paolocipolla View Post
    Thanks rjames,

    do you know if they have been able to see functional returns associated to the regeneration they have obtained?
    Paolocipolla I don't know if they have seen functional return but in March at their Meet the Scientist open house I will find out.

  6. #6
    so just make the pill. lol just one more "tip of the iceberg"

  7. #7
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    Quote Originally Posted by jhope View Post
    so just make the pill. lol just one more "tip of the iceberg"
    Jhope, I agree. We need to do some reverse engineering and take all these icebergs of research and make them into a glacier of a cure!!!!

  8. #8
    Quote Originally Posted by rjames View Post
    Paolocipolla I don't know if they have seen functional return but in March at their Meet the Scientist open house I will find out.
    Thanks rjames.

    As I understand, so far, in the publisced studies thay have sacrificed the mouse soon after treatment to investigate what happened early at the injury site.
    Also, as I understand, they have used transection model, just lately also contusion model (where regeration was a bit less).

    That was several moths ago, maybe a year, so I would guess they have made further progresses now.

    Thanks in advance.

    Paolo
    In God we trust; all others bring data. - Edwards Deming

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    Member Peders's Avatar
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    I wouldn't mind going from a C-4 to a C7!

  10. #10
    Wow, that was interesting! That could be something BIG!

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