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Thread: Feasibility of combination allogeneic stem cell therapy for SCI: a case report

  1. #41
    Dr Ichim,

    In another thread, I was critical of your paper. It is nice that you are posting on Care Cure, and I would like to ask you some questions directly.

    First, I want to say that I sustained a spinal cord injury about ten years ago and have been around this forum most of that time. I have seen many treatments in clinics around the world come and go, and so far, all of them pretty much don't do a damn thing.

    So I run across Medistem and Cell Medicine. I look at the slick Cell Medicine web site and I see a list of the usual diseases and conditions that are treated, anecodotal evidence that these therapies are effective, and that I would have to travel to a country in the developing world to get treated, probably at an expense of tens-of-thousands of dollars. Frankly, I'm tired of seeing desperate people jumping on this bandwagon or that one, spending large amounts of money and risking their lives on apparently worthless procedures. However, I would be ecstatic to see a procedure with clinical evidence that it actually works!

    Earlier in this thread, Dr. Young asked one of my questions about the neurological status of the subject in your case study. Given that this person had substantial motor sparing below his injury, which indicates that he would likely have significant recovery without a medical intervention like this. In addition, the paper states that he received physical therapy throughout the course of treatment. It is well documented that physical therapy does help people, especially those with incomplete injuries. I was ASIA B 24 hours after injury, and am ASIA D and a community ambulator now. Had I had treatments like the person in your case study, it would have been easy to say that the treatments helped me, even if they did nothing. Is it any wonder I'm testy?

    I have looked at the authors of your paper and I don't see anyone with a background in neuroscience or spinal cord injury, though there are a few of the people from Panama or Costa Rica that I could not find any information on. Who are your experts on neuroscience and spinal cord injury?

    I'm also curious about the use of intrathecal injections of cells. Results of that procedure that I've seen reported here on Care Cure and elsewhere appear minimal at best. Why are you going that route? And why should intravenous injections do anything at all? Are you planning any real clinical trials to test these procedures?

    Thank you,
    -Bruce
    Last edited by bruce; 11-29-2010 at 01:58 PM.

  2. #42
    Quote Originally Posted by bruce View Post
    Dr Ichim,

    In another thread, I was critical of your paper. It is nice that you are posting on Care Cure, and I would like to ask you some questions directly.

    First, I want to say that I sustained a spinal cord injury about ten years ago and have been around this forum most of that time. I have seen many treatments in clinics around the world come and go, and so far, all of them pretty much don't do a damn thing.

    So I run across Medistem and Cell Medicine. I look at the slick Cell Medicine web site and I see a list of the usual diseases and conditions that are treated, anecodotal evidence that these therapies are effective, and that I would have to travel to a country in the developing world to get treated, probably at an expense of tens-of-thousands of dollars. Frankly, I'm tired of seeing desperate people jumping on this bandwagon or that one, spending large amounts of money and risking their lives on apparently worthless procedures. However, I would be ecstatic to see a procedure with clinical evidence that it actually works!

    Earlier in this thread, Dr. Young asked one of my questions about the neurological status of the subject in your case study. Given that this person had substantial motor sparing below his injury, which indicates that he would likely have significant recovery without a medical intervention like this. In addition, the paper states that he received physical therapy throughout the course of treatment. It is well documented that physical therapy does help people, especially those with incomplete injuries. I was ASIA B 24 hours after injury, and am ASIA D and a community ambulator now. Had I had treatments like the person in your case study, it would have been easy to say that the treatments helped me, even if they did nothing. Is it any wonder I'm testy?

    I have looked at the authors of your paper and I don't see anyone with a background in neuroscience or spinal cord injury, though there are a few of the people from Panama or Costa Rica that I could not find any information on. Who are your experts on neuroscience and spinal cord injury?

    I'm also curious about the use of intrathecal injections of cells. Results of that procedure that I've seen reported here on Care Cure and elsewhere appear minimal at best. Why are you going that route? And why should intravenous injections do anything at all? Are you planning any real clinical trials to test these procedures?

    Thank you,
    -Bruce

    Hi Bruce, thank you and the other members of this forum for comments and reading the paper.

    Let me mention first my situation. Being CEO of Medistem Inc, my duties are focused on our filed IND with the FDA for treatment of critical limb ischemia using the new stem cell that we discovered, the Endometrial Regenerative Cell.

    The work performed outside of the US is by Cellmedicine who have licensed our technologies but we do not received ongoing royalties after the license agreement was modified more than a year ago. This means that advertising patient treatments is completely outside of Medistem's main scope of interest.

    The paper was written on the first patient that was treated with the combined protocol. I thought it should be reported in the literature because to my knowledge it is the first time that someone has used CD34 and mesenchymal-based cells.

    The concept (and please please comment and critize) was that angiogenesis is beneficial and sometimes critically tied into neurogenesis (thats why CD34s) and that the mesenchymals will provide a suitable environment.

    Because of the licensee-licensor relationship (it can be found on our previous public filings) I do not have all of the data at my fingertips. I am sorry I have not found out exactly how many patients have been treated yet. I do need to find this out for you.

    You are absolutely correct that there are spontaneous remissions. I believe we mentioned this in the paper.

    In no way did I want to give the impression that if someone goes and gets the procedure done, then they will have the same results.

    Given that we filed our IND for our new cells, it may be very useful to file with FDA for spinal cord injury once the first one is approved.

    Thank you for your suggestions, and please, if i forget to get back to you, please email to me directly at thomas.ichim@gmail.com

    Best wishes

    Tom

  3. #43
    Bruce and thomasichem; great posts. I don't cpmletly understand them but the back and forth of real information is good for all of us. We need to know what is real and not. I wish we could get more of this banter on all cures and fake cures. We are getting toi that point on this forum. Again thenk you for the interesting posts.

    keeping on

  4. #44
    Quote Originally Posted by 0xSquidy View Post
    Tomasichim,

    This is what you are saying: we've published a VOID paper that shows NO evidence with NO statistical significance in a LOW IMPACT journal.

    I hope you can do better than that.


    Quote Originally Posted by 0xSquidy View Post
    I understand you've been paralyzed for a long time and seems to me you have lost the hope for a treatment for you. I'm sorry if i'm wrong on that but if i am not, why do you keep visiting the cure forum and posting always the same kind of tune? Lots of people do get discouraged in helping because of comments like that one, maybe you can try harder with your negativity.



    I think Lynnifer is correct. We need better moderators that post things like this. Thanks Squid...

  5. #45
    Hi I foudn the numbers treated by our collaborators...posted it on another thread and now i cant seem to find it !!!

  6. #46
    Hi everyone,

    I see that this topic has been going on here for sometime now, however the past few weeks is the first I have heard of it. The Stem Cell Institute has been mentioned by several of our clients recently.

    I have done some serious digging on the Institute, Medistem, and researcher/CEO Neil Riordan...

    Dr. Neil Riordan - His clinic was recently kicked out of Costa Rica…

    http://www.reuters.com/article/2010/...6516UR20100602

    He also founded/owns the following companies:

    http://www.prlog.org/10778712-stem-k...ewsletter.html

    http://www.stem-kine.com/

    http://www.aidanproducts.com/about.php

    http://immunemedicine.com/


    Other interesting info:

    http://sctmonitor.blogspot.com/2011/...ited-hard.html

    http://www.azcentral.com/arizonarepu...20.html?&wired

    Former shell companies now "biotechs" affiliated with Medistem

    Medistem (formerly SGC Holdings)

    Entest Biomedical (formerly JB Clothing Corp)

    BioMatrix Scientific Group (formerly Tasco Holdings)

    Vivicells International (formerly Tropical Beverage Inc) …this one is really crazy see this link http://investorshub.advfn.com/boards...ge_id=56373982 CEO Kenneth S Wulwick appears to currently be in jail

    As far as I can tell these affiliated "biotechs" are nothing more than Press Release machines to pump and dump OTC and Pink Sheet stocks...
    Last edited by Snowman; 02-25-2011 at 08:09 PM.


    Eric Harness, CSCS
    Founder/President
    Neuro Ex, Inc
    Adaptive Performance and Neuro Recovery

  7. #47
    I found some more interesting details..

    Medistem Corporate Headquarters and Aidan Products have the exact same address:

    http://www.medisteminc.com/contact.php
    http://www.aidanproducts.com/contact.php

    The Aidan Foundation also has the same address:

    http://www.taxexemptworld.com/organi...asp?tn=1225874


    If you look at the San Diego location of Medistem you will find that it has the same address as these companies:

    http://biorasi.com/site/article.php?story=contactus
    http://www.sandscpas.net/sb/deux.jsp?content=501
    http://www.vendevia.com/index_files/Page1672.htm
    http://biorasi.com/oncomune/OncoMune...s/page0006.htm


    Eric Harness, CSCS
    Founder/President
    Neuro Ex, Inc
    Adaptive Performance and Neuro Recovery

  8. #48
    Eric, thanks for posting.

  9. #49
    Definitely a scam...
    In God we trust; all others bring data. - Edwards Deming

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