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Thread: Feasibility of combination allogeneic stem cell therapy for SCI: a case report

  1. #21

    Feasibility of combination allogeneic stem cell therapy for SCI: a case report

    Int Arch Med. 2010 Nov 11;3(1):30.

    Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report.

    Ichim TE, Solano F, Lara F, Paris E, Ugalde F, Paz Rodriguez J, Minev B, Bogin V, Ramos F, Woods EJ, Murphy MP, Patel AN, Harman RJ, Riordan NH.
    Abstract

    ABSTRACT: Cellular therapy for spinal cord injury (SCI) is overviewed focusing on bone marrow mononuclear cells, olfactory ensheathing cells, and mesenchymal stem cells. A case is made for the possibility of combining cell types, as well as for allogeneic use. We report a 29 year old male who suffered a crush fracture of the L1 vertebral body, lacking lower sensorimotor function, being a score A on the ASIA scale. Stem cell therapy comprised of intrathecal administration of allogeneic umbilical cord blood expanded CD34 and umbilical cord matrix MSC was performed 5 months, 8 months, and 14 months after injury. Cell administration was well tolerated with no adverse effects observed. Neuropathic pain subsided from intermittent 10/10 to once a week 3/10 VAS. Recovery of muscle, bowel and sexual function was noted, along with a decrease in ASIA score to "D". This case supports further investigation into allogeneic-based stem cell therapies for SCI.

    http://www.ncbi.nlm.nih.gov/pubmed/21070647
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005

  2. #22
    I moved this post from the research forum in hopes of more comments. I'm curious if Dr. Young is familiar with any of the authors. The first company cited in the article is Medistem (http://www.medisteminc.com/) who apparently had some type of relationship with Beike in the past (http://sci.rutgers.edu/forum/showthr...light=medistem). Free full text is available. I already have a few questions starting with an initial diagnosis of incomplete ASIA A.
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005

  3. #23
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    Any comments from Dr Young about this treatment?

    I am having also same L1 injury.

  4. #24

    Cellmedicine.com spinal cord injury paper published

    Hi, I noticed the discussion and I figured I should share a recent paper we published. Obviously its not "evidence" because it is only one patient...but i think that the rationale and concept put forward should be followed and tested in randomized trials.

    The patient "got better"

    here is the link http://www.intarchmed.com/content/pd...-7682-3-30.pdf

  5. #25

    spinal cord injury stem cell success (one patient)

    Quote Originally Posted by jhope View Post
    there is no therapy yet. no secret doctor that heals you with stem cell therapy. SO STOP THIS BULLSHIT.
    i wish there was a secret doctor...fortunately our work is published in the peer reviewed literature...our latest paper http://www.intarchmed.com/content/pd...-7682-3-30.pdf

  6. #26
    Senior Member 0xSquidy's Avatar
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    Tomasichim,

    This is what you are saying: we've published a VOID paper that shows NO evidence with NO statistical significance in a LOW IMPACT journal.

    I hope you can do better than that.
    Last edited by 0xSquidy; 11-19-2010 at 11:36 AM.
    Don't ask what clinical trials can do for you, ask what you can do for clinical trials.

    Fenexy: Proyecto Volver a Caminar

    http://www.fenexy.org (soon in english too)

  7. #27

    Medistem spinal cord paper

    Quote Originally Posted by wildwilly View Post
    I moved this post from the research forum in hopes of more comments. I'm curious if Dr. Young is familiar with any of the authors. The first company cited in the article is Medistem (http://www.medisteminc.com/) who apparently had some type of relationship with Beike in the past (http://sci.rutgers.edu/forum/showthr...light=medistem). Free full text is available. I already have a few questions starting with an initial diagnosis of incomplete ASIA A.
    Medistem is a US Biotechnology company with a filed IND for critical limb ischemia...some of our technologies are used by www.cellmedicine.com in Panama.

    As anyone in this field, we are very interested in the cutting edge, and that is why we examined some of Beike's data and published it in peer reviewed literature.

    If you have any questions please do not hesitate to contact me directly. thomas.ichim@medisteminc.com

    This forum is amazing and I thank the organizors.

    Tom

    Thomas E Ichim, Ph.D
    Chief Executive Officer
    Medistem Inc
    9255 Towne Centre Drive
    San Diego
    CA 92122
    858 349 3617
    858 642 0027

  8. #28

    thats kinda harsh, no?

    Quote Originally Posted by 0xSquidy View Post
    Tomasichim,

    This is what you are saying: we've published a VOID paper that shows NO evidence with NO statistical significance in a LOW IMPACT journal.

    I hope you can do better than that.
    now that is a very mean thing to say...

  9. #29
    Senior Member 0xSquidy's Avatar
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    Quote Originally Posted by thomasichim View Post
    now that is a very mean thing to say...
    It's not intended to be offensive at all. But please show me where I'm wrong.
    Don't ask what clinical trials can do for you, ask what you can do for clinical trials.

    Fenexy: Proyecto Volver a Caminar

    http://www.fenexy.org (soon in english too)

  10. #30

    lets be objective

    Quote Originally Posted by 0xSquidy View Post
    It's not intended to be offensive at all. But please show me where I'm wrong.
    A famous company that we are know of has attracted significant publicity for using embryonic stem cells in ONLY ONE PATIENT...and they are the heros of everyone because they give "hope"

    in our case the patient underwent a significant improvement not only in mobility but also neuropathic pain, bladder, and sexual function AND MOST IMPORTANTLY a new, clinically-applicable treatment protocol was disclosed that any research institution with a cell processing facility can try to replicate

    not to mention the fact that we had 3 big-name American clinical trials doctors participate in the patient evaluation

    so of course i think that our work is fundamentally important...ESPECIALLY since we shared all the details with everyone

    BUT INSTEAD WHAT HAPPENS IS THAT PEOPLE LIKE YOU HAVE TO GO OUT OF THEIR WAY TO PUT DOWN THE RESEARCH OF MY COLLEAGUES AND COLLABORATORS

    I REALLY DID QUESTION WHY WE EVEN ENTERED THE FIELD OF SPINAL CORD INJURY ....UNLIKE OTHER FIELDS, IT SEEMS THAT MANY PEOPLE IN THIS FEILD ARE MORE EAGER TO PUT DOWN EACH OTHER THAN ACTUALLY COLLABORATE TO GET SOMETHING SOLID AND REAL DONE

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