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Thread: Constitutive 5-HT2C receptor signaling is involved in both recovery and spasticity fo

  1. #1

    Constitutive 5-HT2C receptor signaling is involved in both recovery and spasticity fo

    Constitutive 5-HT2C receptor signaling is involved in both recovery and spasticity following spinal cord injury.

    Following spinal cord injury (SCI) there is immediate paralysis of muscles that are innervated by motor neurons caudal to the injury site, which is followed several weeks later by a restoration of motor neuron excitability. This restoration is associated with recovery of motor function but also with debilitating muscle spasms and occurs through an unknown mechanism. Now, Murray et al. show a role for constitutive activation of the 5-hydroxytryptamine (5-HT) receptor 2C (5-HT2C) in this process, and highlight 5-HT2C inverse agonism as a potential antispastic therapeutic strategy.

    read...

    http://www.signaling-gateway.org/upd...8/nrn2888.html

  2. #2
    Manouli, Wise has said that spasms might be a good think in that the nerves are still alive. I hope that he proves this to be true in his therapies and brings to lifr those of us that are totally paralyzed. I was offered a pump and turned it down. Now if a medication can dampen the spasticity and allow more function, that would be good.

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