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Thread: TCA Cellular Therapeutics

  1. #1

    TCA Cellular Therapeutics

    Wise are you familiar with the phase 1 study of the Veterans Hospital for Veterans? Could you give your understanding of the therapy and will the veterans of the wars have a chance to walk again?

  2. #2
    Quote Originally Posted by keeping on View Post
    Wise are you familiar with the phase 1 study of the Veterans Hospital for Veterans? Could you give your understanding of the therapy and will the veterans of the wars have a chance to walk again?
    I don't know whAt trial you are referring to. Wise.

  3. #3
    http://www.businesswire.com/news/hom...ive-Adult-Stem Wise, anything on this that you might know about?

    thanks in advance
    keeping on

  4. #4
    Wise, any comment?

    keeping on

  5. #5

    TCA Cellular Therapeutics

    Many people have been asking me about this therapy and trial. I do not know any more than what is available on internet.

    http://www.thesttammanynews.com/arti...2936100930.txt

    http://www.businesswire.com/news/hom...ive-Adult-Stem

    It appears that they are growing mesenchymal stem cells from a person's own bone marrow and then transplanting these into the spinal cord. From the description and the fact that the patient was out of the hospital the next day, it seems that they are injecting the cells intrathecally. As I explained elsewhere, I am skeptical that intrathecal injection of the cells will do very much to get the cells into the spinal cord. The cells are most likely to settle in the cauda equina. It is possible that they may provide some growth factors that may stimulate some growth. It will be interesting to see what happens.

    A search of http://clinicaltrials.gov indicated that this company is carrying out several FDA-approved clinical trials:

    1. Completed Combination Stem Cell Therapy for the Treatment of Severe Leg Ischemia
      Conditions: Critical Limb Ischemia; Peripheral Vascular Disease
      Intervention: Biological: Mesendo
    2. Recruiting Phase II Combination Stem Cell Therapy for the Treatment of Severe Coronary Ischemia(CI)
      Conditions: Heart Disease; Blocked Arteries; Coronary Ischemia; Coronary Disease; Coronary Artery Disease; Coronary Atherosclerosis
      Interventions: Biological: MESENDO; Other: placebo
    3. Recruiting Safety/Efficacy Study for the Treatment of Amyotrophic Lateral Sclerosis
      Condition: Amyotrophic Lateral Sclerosis
      Intervention: Biological: autologous bone marrow-derived stem cells
    4. Recruiting Phase II Combination Stem Cell Therapy for the Treatment of Severe Leg Ischemia
      Conditions: Critical Limb Ischemia; Severe Leg Ischemia; Peripheral Artery Disease; Peripheral Vascular Disease
      Interventions: Biological: MESENDO; Biological: Placebo
    5. Active, not recruiting Combination Stem Cell (MESENDO) Therapy for Utilization and Rescue of Infarcted Myocardium
      Conditions: Coronary Artery Disease; Coronary Arteriosclerosis; Coronary Atherosclerosis; Coronary Disease
      Intervention: Biological: MESENDO
    6. Recruiting Transfer of Bone Marrow Derived Stem Cells for the Treatment of Spinal Cord Injury
      Condition: Spinal Cord Injury
      Intervention: Biological: autologous mesenchymal stem cells
    7. Active, not recruiting Combination Stem Cell Therapy for the Treatment of Severe Coronary Ischemia
      Conditions: Coronary Ischemia; Coronary Disease; Coronary Artery Disease; Coronary Atherosclerosis; Coronary Arteriosclerosis
      Intervention: Biological: MESENDO


    Their spinal cord injury trial is described in http://clinicaltrials.gov/ct2/show/N...ellular&rank=6

    According to the clinical trial description, this is the treatment: "Intrathecal infusion of a single dose of ex vivo expanded MSC".

    Wise.
    Last edited by Wise Young; 09-08-2010 at 02:20 AM.

  6. #6
    Senior Member 0xSquidy's Avatar
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    Sad this is intrathecally.
    If they also provide some growth factors, how will they be able to determine if the outcome is due to the cells or due to the factors?
    Don't ask what clinical trials can do for you, ask what you can do for clinical trials.

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