Thread: ChinaSCINet Update

  1. #2471
    PT is a big part of Dr. Wise's method with stem cells. As Jim earlier responded that people who got stem cells but no PT did not improve even though there was axon growth. So PT is a big part of any future treatment.

  2. #2472
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    Quote Originally Posted by scimike View Post
    PT is a big part of Dr. Wise's method with stem cells. As Jim earlier responded that people who got stem cells but no PT did not improve even though there was axon growth. So PT is a big part of any future treatment.
    My question is how did the stem+PT do when compared to only PT?

  3. #2473
    I think Jim also answered it earlier but Stem + PT did very well. This was a phase I so they will increase stem cell amount in the next trial combination with other things (lithium etc). They did not expect much in the trial because of phase I as all phase I trials are pretty much safety studies to make sure it is safe.

  4. #2474
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    Quote Originally Posted by Mize View Post
    To be honest the improvements in walking scores don't persuade me. I'm an ASIA A, complete, T7 and I'm now walking with parallel bars with one PT assisting and afos. That's a pretty decent walking score. I guess I'm saying that it's possible that much or even most of the improvements aren't from stem cells but rather the intense PT effort. I'll be far more optimistic if there's solid evidence of axon growth, bridging and reconnection.
    Quote Originally Posted by DaDutchman View Post
    When I was doing OT within a year after being injured, we concentrated on getting my hand and fingers working. At that time I asked my therapist about my chances in getting full hand function. She stated that I would probably walk before I regained complete hand function. She said the reason was because there are so many nerves and muscles in the hand compared to the legs. I was also informed that return of function did not necessarily happen in a top down order. One PT therapist cited a patient of hers that could walk, but did not only not have hand function, but did not have sensation in their leg. I was wondering if the nerves in the spine reconnected like wires in an electrical cabinet. You know, red to red, yellow to yellow, blue to blue, etc. and if so, how did the body know which ones to connect to. To me that is the biggest mystery of how stem cells will aid in correctly connecting the nerves on each side of the damaged area.
    Oh wow thnxs.. that's how I've ever formed my own view, well guess since there is no data..!
    Forming a generalization of such makes sense in my mind though as that's initially how they paint it out whence your hurt...
    "boom ok your a C-5-6m.. Thats where biceps, shoulders, wrist extensors come in/on"....thEn they educate you of the leveled nervous/spinal system..
    18 month window of possible return, hmm only logically natural i think to count the connection levels//return groups that head down the spine...
    Or something like that...
    I am not your rolling wheels
    I am the highway
    I am not your carpet ride
    I am the sky
    I am not your blowing wind
    I am the lightning
    I am not your autumn moon
    I am the night, the night..

  5. #2475
    Quote Originally Posted by Nowhere Man View Post
    Might be rather dangerous (& bulky) using a roller near a wet shower when you can't feel your legs (assumption) or voluntarily move legs.
    I'll risk it. Sign me up!


  6. #2476
    https://www.researchgate.net/post/Sh...control_or_not

    Urologic status of 74 spinal cord injury patients from the 1976 Tangshan earthquake, and managed for over 20 years using the Cred? maneuver.
    Chang SM1, Hou CL, Dong DQ, Zhang H http://www.ncbi.nlm.nih.gov/pubmed/11035477

  7. #2477
    Quote Originally Posted by scimike View Post
    I think Jim also answered it earlier but Stem + PT did very well. This was a phase I so they will increase stem cell amount in the next trial combination with other things (lithium etc). They did not expect much in the trial because of phase I as all phase I trials are pretty much safety studies to make sure it is safe.
    The ChinaSCINet Phase II Trial was an escalating dose trial. From the Abstract- In HK, four participants received four 4-?L (1.6 million cells) injections into dorsal entry zones above and below the injury site and another four received 8-?L (3.2 million cells) injections. In KM, five groups of four participants received four 4-?L (1.6 million cells), 8-?L (3.2 million cells), 16-?L (6.4 million cells), 6.4 million cells plus 30mg/kg methylprednisolone (MP), or 6.4 million cells plus MP and a 6-week course of oral lithium carbonate.

  8. #2478
    Yesterday, Stemcells made decision to terminate the Company?s Phase II Pathway Study in spinal cord. http://investor.stemcellsinc.com/pho...ews&id=2173446

    SAD.
    Last edited by alan gong; 06-01-2016 at 04:59 AM. Reason: add link

  9. #2479
    It's amazing that company goes under, and what Dr. Young and his team were able to do with far less funds, still moving forward. Probably helps doing it in China First Smart move

  10. #2480
    U.S. is expensive for sure. If there is a breakthrough with any kid of stem cells that made a chronic person stand up and walk a little then a lot of investors would be interested. Maybe I am expecting too much as I was thinking that floodgates would open up with stem cells but most of the trials are safety trials now. I think Grammy said or implied that stem cells have not cured any sickness yet as it is very new and it is in very early clinical trials.

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