Thread: ChinaSCINet Update

  1. #1171

  2. #1172
    The trial referred to above is a phase I trial aimed at establishing the safety of umbilical cord blood mononuclear cell transplants into the brains of patients with middle cerebral artery stroke. It will be carried out at the Chinese University of Hong Kong and Hong Kong University. A total of 6 patients will be transplanted and compared against 6 matched non-transplanted control patients with similar strokes, ages, and times after stroke. In addition to helping our colleagues with the logistics of carrying out this stroke trial at the Chinese University of Hong Kong and Hong Kong University, this trial will establish the safety of injecting cells into the brain. We are also interested in the safety of brain transplants for spinal cord injury for the following reasons:

    Brain transplants may be something that we may need to do to treat spinal cord injury, because it delivers growth factors close to the neurons that we want to grow their axons. Dr. John Lin and colleagues in Taiwan (submitted for publication) recently showed that injection of peripheral blood CD34+ mononuclear cells into the brain can remarkably stimulate regeneration of the corticospinal tract and restore function in people with chronic stroke. However, older patients have fewer CD34+ cells and they apparently did not recover as well. Of course umbilical cord blood CD34+ cells are the youngest and presumably more potent.

    Thus, it is of interest to determine whether CD34+ mononuclear cells from HLA-matched umbilical cord blood would have the same effect as autologous peripheral blood CD34+ mononuclear cells. Injection of cells into the brain may be a rational target for stimulating corticospinal tract regeneration in patients with tetraplegia, for example. The trial is sponsored by Stemcyte and we are not using any spinal cord injury trial funds raised in Hong Kong to do the trial.


  3. #1173
    Quote Originally Posted by mamadavid View Post

    Although your question was for Dr Young I'll take the liberty of replying to the best of my ability. I had the privilege of meeting Dr Zhu and observing her walking programme last March. I also visited the new private hospital where she has since transferred her operation. The hospital is called Tongren Hospital and is part of a group of private hospitals in China owned by a Hong Kong businessman. The facility is brand new and was partially up and running when I visited. It is huge and modern. I was given a guided tour by the assistant general manager and it seemed to be well equipped with the latest medical hardware. I was shown the VIP rooms and VIP suites where I was told the overseas patients would stay -- good beds, accessible bathrooms, flat screen TVs, nicely decorated -- no cause for complaint. However, as I pointed out to Dr Zhu, most if not all of the overseas patients who will be interested in attending her walking programme will be chronically injured people who will not need or want to stay in a hospital room. They will be there for the rehab and apart from that will be "normal" people living in a "normal" way. As far as I could see the VIP rooms and suites were for the hospital as a whole, not just for Dr Zhu's patients, so one can assume that they will be accommodating very sick people, people recovering from surgery, etc., and needing a very quiet, very medicalised environment. I told Dr Zhu that the people who would be coming from overseas for the walking programme would probably be happier with another type of accommodation -- say apartments where they could share equipment and carers, cook, listen to music, etc. She has since written to me (my son is planning to attend her programme at the end of the summer) that she is planning on offering foreign patients pleasant, family-like living arrangements. I'm not sure what she has planned but I will be seeing her on June 12 and will get all the details from her.
    I cannot tell you how impressed I was with Dr Zhu and her team. Never have I seen a more caring, positive, altruistic person than Dr Zhu (apart from Wise Young of course!). Seeing her patients at various stages of walking was such an inspiration and I am convinced that her programme is the best next step for my son.
    I know so many of you will want to know more details -- cost and duration of the programme, what kind of nursing care and assistance can be provided, etc. I can't answer these questions now but will be finding out in the next few weeks. I'll share all the answers as soon as I have them.

  4. #1174
    I am also wondering about progress of report that mamadavid has promised in June this year about private Tongren Hospital in Kunming and Dr. Zhu Hui start to work there.
    Dr. Wise was also explaining about Dr. Zhu new start after retirement in this private clinic.
    Is anyone get any news?
    How realistic will be to see faster implementation of UCBMC + lithium (or similar) procedure in private clinic as Tongren or any other ?

    Miracles are not contrary to nature, but only contrary
    to what we know about nature
    Saint Augustine

  5. #1175


    what is strange not the name of dr zhu hui on the website of the hospital and nothing on the internet and read in on a site that Chinese hui zhu retired definitive

  6. #1176
    Dr. Zhu Hui was required to retire from the Army due to her age.
    She is now at a private hospital where she will continue her career. This private hospital will be accepting visiting patients. This is all I know.

  7. #1177
    the comment above professor thank you

  8. #1178
    At the spinal cord workshop of today Wise has given un update on the trials at chinaSCINet.
    Videos are available here:

    It is interesting that Wise said that the patients didn't improve motor and sensory score, but some of them walk... ???

    In God we trust; all others bring data. - Edwards Deming

  9. #1179
    Senior Member lunasicc42's Avatar
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    Quote Originally Posted by paolocipolla View Post
    At the spinal cord workshop of today Wise has given un update on the trials at chinaSCINet.
    Videos are available here:

    It is interesting that Wise said that the patients didn't improve motor and sensory score, but some of them walk... ???


    Paolo, I thought that too, was the jist of it that the rehab regimen improved walking function and ucbmc doesn't really do anything? As to sensory and bbb???
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  10. #1180
    They recovered some walking without increase in motor function or sensory?

    Also, regrowing spinal cord tissue might not help functional recovery?

    Maybe I misunderstood what he said.

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