Thread: ChinaSCINet Update

  1. #1151
    Quote Originally Posted by Buck503 View Post
    SOURCE

    Just correcting your timeline here, Jim. No impatience with Wise Young.
    Really? So, there is potentially data on someone close to two years post (albeit at the lowest dose)...

  2. #1152
    Quote Originally Posted by Barrington314mx View Post
    i hope i get the nay sayers spot in line when Wise succeeds with this.
    "I'm manic as hell-
    But I'm goin' strong-
    Left my meds on the sink again-
    My head will be racing by lunchtime"

    <----Scott Weiland---->

  3. #1153
    Wow, time flys, thanks Buck.

    This is a safety trial and can already be considered a success. The surgeries and injections have proven to be safe. Any return of function or growth within the spinal cord is gravy. ChinaSCINet is now an established clinical trial network ready to test the most promising therapies. 7-8 years of hard work by many, many dedicated people.

  4. #1154
    Quote Originally Posted by Jim View Post
    Wow, time flys, thanks Buck.

    This is a safety trial and can already be considered a success. The surgeries and injections have proven to be safe. Any return of function or growth within the spinal cord is gravy. ChinaSCINet is now an established clinical trial network ready to test the most promising therapies. 7-8 years of hard work by many, many dedicated people.
    Jim, is there any way to see the funding numbers?

  5. #1155
    Quote Originally Posted by Barrington314mx View Post
    Jim, is there any way to see the funding numbers?
    Planning a cost/benefit analysis?

  6. #1156
    I have no idea what the ChinaSCINet funding numbers are. All the money was raised in Hong Kong and China.

  7. #1157
    Jim, How can you say that it is already a success ? It just shows that it is safe to transplant USBC in the spinal cord, for me success means functional return. Alok Sharma , Carlos Lima have been transplanting cells of different kinds for many many years , so we know that bone , olfactory cells are also safe , but what have the patients gained ?

  8. #1158
    Establishing a clinical trial network with 26 Centers and conducting a Phase II safety trial which proved to be safe is a huge deal. The fact that this surgery is safe is no trivial matter. Opening the dura and exposing the spinal cord can be risky, now we know it can be done safely. Any return of function is a bonus.

  9. #1159
    Senior Member khmorgan's Avatar
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    Quote Originally Posted by lakboy View Post
    Jim, How can you say that it is already a success ? It just shows that it is safe to transplant USBC in the spinal cord, for me success means functional return. Alok Sharma , Carlos Lima have been transplanting cells of different kinds for many many years , so we know that bone , olfactory cells are also safe , but what have the patients gained ?
    Unless I missed something, ChinaSCINet is in Phase 2 trials, not Phase 1. By definition, Phase 2 is testing for effectiveness as well as safety. See: http://en.wikipedia.org/wiki/Clinical_trial

    In Phase 2 trials, the experimental treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.

    I would expect that if none of the patients showed any improvement in mobility, they would not move to Phase 3. But, if half showed significant improvement, they might analyze the results more to try to determine if it was a placebo effect or if the procedure needed to be refined. Of course, if all showed improvement, I would expect Phase 3 to proceed quickly.

    Regardless, they will learn something that will aid the next treatment's clinical trial.

    What confuses me is why people who consider a cure to be a "joke", even read this forum.
    Last edited by khmorgan; 10-11-2012 at 09:25 AM.

  10. #1160
    Quote Originally Posted by lakboy View Post
    Jim, How can you say that it is already a success ? It just shows that it is safe to transplant USBC in the spinal cord, for me success means functional return. Alok Sharma , Carlos Lima have been transplanting cells of different kinds for many many years , so we know that bone , olfactory cells are also safe , but what have the patients gained ?
    Lakboy,

    As you know, Alok Sharma has not transplanted cells into the spinal cord. He has only given the cells intrathecally. Both institutional review boards and government regulatory agencies in India have been very resistant to the concept of surgically exposing the spinal cord to transplant cells into the spinal cord. So, your statement that "we know that bone <marrow>, olfactory cells are also safe" is not accepted in India or most places around the world. From that perspective, the demonstration that the treatments are safe is a critical and necessary step to getting such therapies to be allowed and approved in India and most other countries in the world.

    I wish that people would not jump to conclusions about efficacy of umbilical cord blood and lithium before data becomes available. Just because I am not trumpeting the results of not-yet-completed trials does not mean that the treatments are not having beneficial effects. I wish also to remind people that only the 6 month results will be available in December. It is too early to expect dramatic functional results from regeneration.

    Wise.

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