Hi folks, this summary below from the latest "Nature" journal.
My lay understanding of the signifigance of this is that this is proof that neural stem cells exist in the adult mammalian brain. The next trick is to work out how to stimulate and regulate them to grow into the cell you want. A true kind of "self repair", no transplant required.

By the by, Perry Bartlett, the head of the team here, is one of the leading guys in Australia working on SCI repair.

Anyway, here it is

"Purification of a pluripotent neural stem cell from the adult mouse brain

RODNEY L. RIETZE*, HELEN VALCANISt, GORDON F. BROOKER*, TIM THOMAS*, ANNE K. VOSS* & PERRY F. BARTLETT*

* The Walter and Eliza Hall Institute of Medical Research, Royal Parade, Parkville, Victoria 3050, Australia
t Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia

The adult mammalian central nervous system (CNS) contains a population of neural stem cells (NSCs) with properties said to include the generation of non-neural progeny. However, the precise identity, location and potential of the NSC in situ remain unclear. We purified NSCs from the adult mouse brain by flow cytometry, and directly examined the cells' properties. Here we show that one type of NSC, which expresses the protein nestin but only low levels of PNA-binding and HSA proteins, is found in both ependymal and subventricular zones and accounts for about 63% of the total NSC activity. Furthermore, the selective depletion of the population of this stem cell in querkopf mutant mice (which are deficient in production of olfactory neurons) suggests that it acts as a major functional stem cell in vivo. Most freshly isolated NSCs, when co-cultured with a muscle cell line, rapidly differentiated in vitro into myocytes that contain myosin heavy chain (MyHC). This demonstrates that a predominant, functional type of stem cell exists in the periventricular region of the adult brain with the intrinsic ability to generate neural and non-neural cells."

Nature 412, 736 - 739 (2001) © Macmillan Publishers Ltd.

Nature © Macmillan Publishers Ltd 2001 Registered No. 785998 England