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Thread: Improving Recovery From Spinal Cord Injury; Treated Rats Regain Limb Control

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    Improving Recovery From Spinal Cord Injury; Treated Rats Regain Limb Control

    Wed Jun 9 08:09:56 2010 Pacific Time

    Improving Recovery From Spinal Cord Injury; Treated Rats Regain Limb Control

    BALTIMORE, June 9 (AScribe Newswire) -- Once damaged, nerves in the spinal cord normally cannot grow back and the only drug approved for treating these injuries does not enable nerve regrowth. Publishing online this week in the Early Edition of the Proceedings of the National Academy of Sciences, researchers at the Johns Hopkins University School of Medicine show that treating injured rat spinal cords with an enzyme, sialidase, improves nerve regrowth, motor recovery and nervous system function.

    "This is the first functional study showing behavioral improvement below a spinal cord injury by the delivery of sialidase," says Ronald Schnaar, Ph.D., a professor of pharmacology and molecular sciences at Johns Hopkins. "Sialidase has properties that are appealing from the human drug development point of view."

    Sialidase is a bacterial enzyme that removes specific chemical groups found on the surface of nerve cells. The chemical groups normally function to stablize the cells, but also act to prevent nerve regeneration.


  2. #2
    Manouli, what does this mean? What does Wise say about this?

  3. #3
    Senior Member KIM's Avatar
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    Jul 2001
    Piedralaves (Avila) SPAIN
    Finally, the team looked at the nerve ends under a microscope and found that indeed, treated nerves showed an increased number of "sprouted" nerve ends, which according to Schnaar, provided anatomical evidence to add to the functional evidence that "something is going on."

    "The positive is that we have shown functional recovery in a relevant animal model of spinal cord injury," says Schnaar. "That being said, we haven't done full toxicity studies on these rats, which definitely needs to be done before we think about taking the long road into using this as a drug in people; efficacy in animals also doesn't necessarily translate to humans."

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