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Thread: 4ap trial for chronics?

  1. #1
    Senior Member lunasicc42's Avatar
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  2. #2
    It looks like a trial to reduce spasticity in incompletes. This is a nice excerpt: " that is, reduction in spasticity as well as improved sexual function and increased bowel and bladder control. "

    Wonder why they won't test on completes?

  3. #3
    Quote Originally Posted by t8burst View Post
    It looks like a trial to reduce spasticity in incompletes. This is a nice excerpt: " that is, reduction in spasticity as well as improved sexual function and increased bowel and bladder control. "

    Wonder why they won't test on completes?
    As I understand it, 4-AP just "amplifies" weak signals. If you're
    a complete, you have nothing (signals) to start with.

  4. #4
    I believe that is an old, outdated press release. That trial is over, and while criticized for testing spacticty/tone reduction rather than motor gains, it was ultimately not approved.

    See the other 4AP thread a few posts down or the direct link here:
    http://sci.rutgers.edu/forum/showthread.php?t=123961

    From that thread, it seems to be nearing availability for MS patients and some SCIs are trying to get their hands on some for off label use in individual trials.
    C4 incomplete April 26, 2009

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  5. #5
    I was in a 4-AP trial years ago, improved spasms a little and sexual function a good deal.

  6. #6
    Yep, maglito, that's my understanding as well.

    Neither Dr. Young or the company can suggest using Fampridine for people with SCI/D, but you might find a doc who will write you a script for off-label use. You may have to pay for it our-of-pocket though -- insurance companies often deny coverage for off-label meds.

    Anyone have a sense of what the cost of the drug might be when it's finally available?
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  7. #7
    If 4ap shows benefit to us, the rest will take care of itself. I puit my money on what Wise says about 4ap. Let's get categoric recomendations from Wise.

  8. #8
    TJ,
    If you read the thread I linked above you will see Dr. Wise Young will not be able to recommend it for use in SCI until approved for that application by the FDA which they are no longer pursuing.
    C4 incomplete April 26, 2009

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