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Thread: Lyrica Dosage

  1. #21
    Here is a study done in 2006 on Lyrica for SCI.

    http://www.medscape.com/viewarticle/548374

    Pregabalin Effective for Neuropathic Pain After Spinal Cord Injury

    The average dose of pregabalin after the 3-week stabilization phase was 460 mg/day.

    The most common adverse events with treatment were mild to moderate somnolence and dizziness, which were typically transient, they write. Edema occurred more often with pregabalin, in 20% of patients, vs 6% on placebo, and peripheral edema occurred in 10% of the pregabalin patients.

    Just for interest (sorry, not directly pertinant to Neo except listing the doses they are testing) there is a current study going on with Lyrica and SCI patients apparently:

    http://clinicaltrials.gov/ct/show/NCT00407745?order=16

    17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury

    The purpose of this study is to evaluate if pregabalin relieves nerve pain associated with spinal cord injury compared to placebo (pill that contains no active medicine). This study will also evaluate the safety of pregabalin in this patient population

    Pregabalin capsules taken twice daily up to 17 weeks (150-600 mg/day)

  2. #22
    Sjean,.... "I think Med100 was just trying to clarify whether your information came from any experience with a sci (sorry if I am mis-interpreting you Med100)..."

    Yes, That is correct. Thanks :-)

  3. #23
    It feels strange responding to a poster called Neo (Trinity is actually my real name!)

    With regards to Lyrica for break through pain I have, on several occasions, doubled up my dose on days when I get really bad pain with fair effect.
    I normally take 175mg 3xday, I found I got much better pain cover with 3x rather than twice a day
    [IMG]file:///Users/Mememe/Library/Caches/TemporaryItems/moz-screenshot.jpg[/IMG]

  4. #24
    The pain docs I know seem to prescribe 3 times a day usually. It would seem logical from a side effects and coverage standpoint.

    What I did see sometimes was, it'd be twice a day or three times, depending upon the total dose they were trying to prescribe and the mg the pills came in. Whichever added up easier. But I still think 3 times was prescribed more often.

    I do not know this for a fact, but it almost seems that the number of times per day is whatever works for you (I wouldn't think taking one huge dose would be advisable though).

  5. #25
    TAM, just a suggestion, but if you don't know, as you state in the post above, and you are ab, your husband does not live with paralysis, why offer a suggestion about what you think works and/or post you don't know? Why not just read if that is where your bent is? Why post if it's a subject you are not dealing and living with personally and you're just grabbing generic info elsewhere?

    I'm just not getting it somehow.

    Any of us may use Google, check WebMD or whatever sites you're hitting for general, generic, one size fits some info.

    We get the drug interaction and possible side fx info sheets when we have our rx-es filled. That sheet is included with the med from most places whether a chain or indie pharm. We may not keep it if we've taken a medication previously because we think we know or because previously we have not had unwanted side fx.

    Often we learn most and best from each other, from actual, real life, yep, I live with paralysis (or my spouse does) and it's happening/happened to me, too, experiences. If we just wanted to know what any old generic info said, we could Google or bing or whatev.

    As most of us know, too many of our own physicians have not well understood paralysis and SCI. When those individuals don't, you can imagine how well Google/WebMD/whatever else you post will fit us.

    I'm not attempting to be rude, just offering a suggestion. If you are not **taking/using/performing/prescribing/dispensing** the **med/device/procedure/exercise/etc.** for paralysis, and don't have direct, personal experience with the aforementioned, aren't paralyzed in some way and/or don't have SO with paralysis, why guess, write you don't know or grab generic info off the web "for" us?

    Finally, to the OP and others wondering about direct experience with Lyrica for pain and any possible side effects, it caused me near immediate weight gain and severe depression. I don't do depressed and I'm too short to gain weight like I did. I was weaned off, switched back to gabapentin. The horrid depression began to lift. The crazy weight ballooning stopped.

    I'm working to lose the weight through healthy eating and exercising. It's slow going, but I'll get there.

    I've weaned again from gabapentin other than what is necessary for seizure control (it does double duty w/another anti-ep med), and managing to function. For pain management I'm using adaptive yoga, meditation, p/t to help strengthen and better use what I can and the low dose gabapentin. At the greatly reduced dose, the gabapentin is not causing brain fog.

    Hope you find what works for you.

  6. #26
    You know, I didn't just grab generic info. For my husband's privacy, I don't disclose all our details. Especially given recent events.

    But fine - you can win. I didn't join the site to be stressed out. Thanks to Wise and those who have been helpful.

  7. #27
    Thanks guys, I just started taking 150mg 3x a day every 6 hours and will see what happen. How long does it usually take for it to work ? I only have one strip and don't know if that will be enough.

    LaMemChose, yes I did notice that I have gained weight, I didn't know if its from my meds or just my lack of exercise. It may be a combination of both though. I also can't stop the drug because of my pain, but I will definitely try to find a pain doc when I get to the US and hopefully we will find something that works.

    I appreciate your help CC.

    - Neo

  8. #28
    Senior Member
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    Neo, I haven;t gained weight, but I understand from others I have talked to I am in the minority .... so you probably want to keep an eye on that. Those that gained, did so very quickly too I believe.
    T7-8 since Feb 2005

  9. #29
    You ain't kidding on the weight gain! I've only been taking it less than two months and already I've noticed a considerable change in my waistline. I have to really watch what I eat now. I'm hungry all the time.

    You might want to get some more Lyrica ready before you run out Neo, the withdrawl is nasty.

  10. #30
    I was bedridden for a long time because of a nasty bed sore so I didn't know if it were from that or Lyrica. I will keep an eye on the weight gain for sure.

    I am noticing a difference already, the pain seems to be less and yesterday I went for about 7 and a half hours before noticing that I need my next dose. I'm not sure if it's real or placebo but I'm happy either way.

    I still have stock of the 75mg capsules, I can take two at a time until my next order. I will get 150mg from now on. I know better than to stop Lyrica cold turkey. From what I read withdrawal is really a bitch.

    - Neo

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