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Thread: A New Role for RPTP in Spinal Cord Injury: Signaling Chondroitin Sulfate Proteoglycan

  1. #1

    A New Role for RPTP in Spinal Cord Injury: Signaling Chondroitin Sulfate Proteoglycan

    A New Role for RPTP in Spinal Cord Injury: Signaling Chondroitin Sulfate Proteoglycan Inhibition
    Yuntao Duan and Roman J. Giger*

    Department of Cell and Developmental Biology and Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

    Abstract: It has been known for more than two decades that chondroitin sulfate proteoglycans (CSPGs) inhibit axonal growth and regeneration. In the adult nervous system, CSPGs are enriched in perineuronal nets, and their abundance is increased in reactive astrocytes following injury to brain or spinal cord. Degradation of chondroitin sulfate (CS) sugar moieties by the local infusion of the bacterial enzyme chondroitinase ABC (ChaseABC) enhances experience-dependent neuronal plasticity in the adult visual cortex and results in substantially improved behavioral outcomes after spinal cord injury (SCI). Although the positive effects of ChaseABC treatment on neuronal plasticity have been known for some time, the underlying mechanisms remained enigmatic. continue: http://stke.sciencemag.org/cgi/conte.../110/pe6?rss=1

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    This is indeed exciting. The discovery of the receptor for CSPG is very important and is providing new therapeutic targets. I am anticipating new regenerative therapies to come out of this discovery. Wise.

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    Wise, does this finding have any relevance to your project. What possible effects does this have for spinal damage?

    thanks,
    T.J.

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