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Thread: Nanoparticle injection increases stem cell production by 200%

  1. #1

    Nanoparticle injection increases stem cell production by 200%

    Nanoparticle injection increases stem cell production by 200%


    11/23/2009
    Erin Podolak


    Researchers at the University of Texas, Arlington have announced that a new mechanism for reducing scar tissue may hold the key to using adult stem cells to grow new tissues.

    Researchers at the University of Texas, Arlington were developing a nanoparticle injection to reduce scar tissue formation at catheter implantation sites when they discovered a 200% increase in stem cell production in these areas. “Our initial focus was to isolate cells which are recruited to the surface of medical implants in the peritoneal cavity,” said lead researcher Liping Tang, a professor of bioengineering, to BioTechniques. “Surprisingly, we later found that many of these immigrated cells possess stem cell properties and were highly proliferative.”

    http://www.biotechniques.com/news/Na...es-181251.html

  2. #2
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    Okay lots of testing on rats. What about clinical trials on humans?

  3. #3
    Quote Originally Posted by manouli View Post
    Nanoparticle injection increases stem cell production by 200%


    11/23/2009
    Erin Podolak


    Researchers at the University of Texas, Arlington have announced that a new mechanism for reducing scar tissue may hold the key to using adult stem cells to grow new tissues.

    Researchers at the University of Texas, Arlington were developing a nanoparticle injection to reduce scar tissue formation at catheter implantation sites when they discovered a 200% increase in stem cell production in these areas. “Our initial focus was to isolate cells which are recruited to the surface of medical implants in the peritoneal cavity,” said lead researcher Liping Tang, a professor of bioengineering, to BioTechniques. “Surprisingly, we later found that many of these immigrated cells possess stem cell properties and were highly proliferative.”

    http://www.biotechniques.com/news/Na...es-181251.html
    It is almost amusing.

    As described, this study suggests that the researchers did not find a way to reduce glial scarring but rather found a way to attract stem cells. Please note that gliosis at the injury site is likely to reflect increased neural stem cell activity. Neural stem cells make astrocytes. So, they may have found a way to increase gliosis.

    The article is singularly uninformative and poorly written, as were the comments of the lead investigator. For example, they say they are injecting nanoparticles but neglected to say whether the nanoparticles are treated in any way. What kind of controls did the investigator use and was this increase just reflective of damage to the tissue.

    Note that injury itself attracts stem cells. They would have similar results if the nanoparticles simply cause ischemia or otherwise damaged the tissues. Nanoparticles (because they are foreign particles) attract macrophages and macrophages attract stem cells.

    Wise.

  4. #4
    Quote Originally Posted by chesmo View Post
    Okay lots of testing on rats. What about clinical trials on humans?
    Chesmo,

    It is important that we be more critical. Just because some investigator puts out a press release on something doesn't mean that this is something that should be tried on humans. I am not impressed at all by what this article is reporting and don't think that this is ready for clinical trial at all. It sounds like very preliminary data.

    Wise.

  5. #5
    Senior Member NW-Will's Avatar
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    Thank you for taking the time to informatively comment on this Dr. Young.

  6. #6
    Wise, thank you for your insight and time to reply and educate. We are looking for something that not only means something, but will be human ready soon.

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