Stem Cells. 2009 Nov 10.

Challenges of Stem Cell Therapy for Spinal Cord Injury: Human Embryonic Stem Cells, Endogenous Neural Stem Cells or Induced Pluripotent Stem Cells?
Ronaghi M, Erceg S, Moreno-Manzano V, Stojkovic M.

Cellular Reprogramming Laboratory, CIPF, Valencia, Spain.

Spinal cord injury (SCI) causes myelopathy, damage to white matter and myelinated fiber tracts that carry sensation and motor signals to and from the brain. The gray matter damage causes segmental losses of interneurons and motorneurons and restricts therapeutic options. Recent advances in stem cell biology, neural injury and repair, and the progress towards development of neuroprotective and regenerative interventions are the basis for increased optimism. This review summarizes the pathophysiological mechanisms following SCI and compares human embryonic, adult neural and the induced pluripotent stem cell-based therapeutic strategies for SCI.A brief summary of pathophysiological events following spinal cord injury.