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Thread: Master regulator found for regenerating nerve fibers in live animals

  1. #1

    Master regulator found for regenerating nerve fibers in live animals

    Public release date: 25-Oct-2009
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    Contact: James Newton
    Children's Hospital Boston

    Master regulator found for regenerating nerve fibers in live animals

    Enzyme could lead to a possible treatment for brain and spinal cord injury
    Boston, Mass. -- Researchers at Children's Hospital Boston report that an enzyme known as Mst3b, previously identified in their lab, is essential for regenerating damaged axons (nerve fibers) in a live animal model, in both the peripheral and central nervous systems. Their findings, published online by Nature Neuroscience on October 25, suggest Mst3b – or agents that stimulate it – as a possible means of treating stroke, spinal cord damage and traumatic brain injury. Normally, neurons in the central nervous system (the brain and spinal cord) cannot regenerate injured nerve fibers, limiting people's ability to recover from brain or spinal cord injuries.

    The study, led by Nina Irwin, PhD and Larry Benowitz, PhD, of the Laboratories for Neuroscience Research in Neurosurgery and the F.M. Kirby Neurobiology Center at Children's, builds on previous discoveries in the lab. In 2002, they showed that a naturally occurring small molecule, inosine, stimulates axon regeneration, later showing that it helps restore neurological functions in animal models of injury. In 2006, Benowitz and colleagues reported a previously unknown growth factor, oncomodulin, to have dramatic effects on axon growth.


  2. #2
    Senior Member lunasicc42's Avatar
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    Oct 2004
    Lutz, Fl USA*********C456
    this sounds like it could be promising

    Im ah get some Mst3b while I watch mst3k!!
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