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Thread: Applications of Human Umbilical Cord Blood Cells in CNS Regeneration

  1. #1

    Applications of Human Umbilical Cord Blood Cells in CNS Regeneration

    Curr Stem Cell Res Ther. 2009 Oct 7.

    Applications of Human Umbilical Cord Blood Cells in Central Nervous System Regeneration.

    Herranz AS, Gonzalo-Gobernado R, Reimers D, Asensio MJ, Rodr├*guez-Serrano M, Baz├ín E.

    Servicio Neurobiolog├*a-Investigaci├│n, Laboratorio Neurobiolog├*a C├ęlulas Madre, Hospital Ram├│n y Cajal - SERMAS; 28034 Madrid, Spain. antonio.sanchez@hrc.es.

    In recent decades, there has been considerable amount of information about embryonic stem cells (ES). The dilemma facing scientists interested in the development and use of human stem cells in replacement therapies is the source of these cells, i.e. the human embryo. There are many ethical and moral problems related to the use of these cells. Hematopoietic stem cells from umbilical cord blood have been proposed as an alternative source of embryonic stem cells. After exposure to different agents, these cells are able to express antigens of diverse cellular lineages, including the neural type. The In vitro manipulation of human umbilical cord blood (hUCB) cells has shown their stem capacity and plasticity. These cells are easily accessible, In vitro amplifiable, well tolerated by the host, and with more primitive molecular characteristics that give them great flexibility. Overall, these properties open a promising future for the use of hUCB in regenerative therapies for the Central Nervous System (CNS). This review will focus on the available literature concerning umbilical cord blood cells as a therapeutic tool for the treatment of neurodegenerative diseases.

    http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
    ÔÇťAs the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet themÔÇŁ Ramer et al 2005

  2. #2
    Wildwilly Will the announcment this week of allowing the new stem cells for research ansewer or move these projects forward? Let's hope it will allow further progress in this field.

    T.J.

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