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Thread: Acorda Therapeutics Announces Positive Vote by FDA Advisory Committee for Fampridine-

  1. #11
    Senior Member
    Join Date
    Jun 2005
    Location
    Lansing,Il. USA
    Posts
    246

    Cool Da Prove it

    "the science to cure sci is here" is your quote, prove it. As far as I know no animal, rat or otherwise has been "cured". They may have recovered significant recovery, but cured as to being what they were before sci I don't think so. Please prove me wrong with scientific data

    For sci's to be cured as to what we were before our sci's is almost impossible to fathom at least in my lifetime. It takes any drug or therapy to get through the FDA process anywhere from 3-10 years and as I said before it's going to take combination therapies to get what most of us want, A total cure, but yes impressive functional recovery is just around the corner

  2. #12

    Wink

    Quote Originally Posted by znop View Post
    "the science to cure sci is here" is your quote, prove it. As far as I know no animal, rat or otherwise has been "cured". They may have recovered significant recovery, but cured as to being what they were before sci I don't think so. Please prove me wrong with scientific data

    For sci's to be cured as to what we were before our sci's is almost impossible to fathom at least in my lifetime. It takes any drug or therapy to get through the FDA process anywhere from 3-10 years and as I said before it's going to take combination therapies to get what most of us want, A total cure, but yes impressive functional recovery is just around the corner
    I wish I knew which corner is the impressive functional recovery so I can go there and wait in line. I hope u r right!

  3. #13

    Unhappy

    Quote Originally Posted by manouli View Post
    I wish I knew which corner is the impressive functional recovery so I can go there and wait in line. I hope u r right!
    me to it must be a round corner ? can not find the start or the end of it just keeps going round and round

  4. #14
    Senior Member
    Join Date
    Jun 2005
    Location
    Lansing,Il. USA
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    246

    Cool to manouli

    save youself a lot of time and bs that goes around these forums by just following what drug or therapy is started in an FDA trial, and use common sense and Dr Young's advice

    c-7 quad post 18 years
    chicago

  5. #15
    Wise, Purdue University just published a report on a drug that is 10x more powerful than Acorda;s. What do you think, aand what is next step since Acorda's drug took so long for approval from FDA. Given this information and your, as well as our, dismay over length of time for approval. What do we have to loolk forward with your trials in 2010. What can we do?

    T.J.

  6. #16
    Lynnifer, I too have or had transverse myelits. What do you know as to the potential treatments and drugs for possible trials for transverse myelitis?

    Thanks in advance.

  7. #17
    Znop, does this mean we have a better chance with breakthroughs from abroad? Are you looking at any?

  8. #18
    Quote Originally Posted by DA View Post
    if 4-ap was a sex drug, would it had taken this long?
    From my experience and talking with others in the Fampridine-SR clinical trials this drug works like Viagra. Maybe it should have been marketed for erectile dysfunction.
    The test of success is not what you do when you are on top. Success is how high you bounce when you hit the bottom
    --General George Patton

    Complex problems need to be solved collectively.
    ––Paul Nussbaum
    usc87.blogspot.com

  9. #19
    Quote Originally Posted by PN View Post
    From my experience and talking with others in the Fampridine-SR clinical trials this drug works like Viagra. Maybe it should have been marketed for erectile dysfunction.
    Paul,

    I better chime up before Fampridine is rumored to be a sex enhancing drug. Fampridine does not act like Viagra. To my knowledge, it does not increase erections. It may increase sensation in people who have loss of sensation due to demyelination and thereby facilitate ejaculation but, to my knowledge, this has never been tested or documented.

    Fampridine is a 4-aminopyridine, a drug this known to block the fast voltage sensitive potassium channel in neurons. This channel participates in action potentials in neurons, heart, and other excitable tissues. Normally, the fast voltage-sensitive potassium channel opens when membranes depolarize.

    Let me give a specific technical explanation. When a neuron fires an action potential, it opens up sodium channels and the expression of the sodium Nernst potential across the sodium channel causes membrane potential to fall towards zero (depolarize). Depolarization opens up the potassium channel and the expression of the potassium Nernst potential across the potassium channels causes membrane potential to become more negative (hyperpolarize), thereby closing the sodium channels. The physiological function of the fast voltage sensitive potassium channel is to shorten the duration of the action potential. Therefore, 4-aminopyridine, by blocking the potassium channel, increases the duration of action potentials. This has two effects. First, due to the increased duration of action potentials, the action potential is more likely to cross demyelinated zones. Second, the amount of neurotransmitter released depends on the duration of depolarization at the end of the axons. So, fampridine increases the amount of neurotransmitter released per action potential that gets to the synaptic ending.

    Wise.

  10. #20
    thats not english !

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