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Thread: Pluripotent Stem Cells Derived from Adult Human Testes.

  1. #1

    Pluripotent Stem Cells Derived from Adult Human Testes.

    Stem Cells Dev. 2009 Mar 12.

    Pluripotent Stem Cells Derived from Adult Human Testes.

    Gallicano GI, Golestaneh N, Kokkinaki M, Pant D, Jiang J, Destefano D, Fernandez-Bueno C, Rome JD, Haddad BR, Dym M.

    Georgetown University Medical Center, Biochemistry and Molecular & Cellular Biology, Washington, District of Columbia, United States, 202-687-1823; gig@georgetown.edu.

    Recent reports have demonstrated that adult tissue cells can be induced to pluripotency, the iPS cells, mostly with the addition of genes delivered using viruses. Also, several publications both in mouse and human have demonstrated that spermatogonial stem cells from testes can covert back to embryonic stem (ES)-like cells without the addition of genes. Furthermore, these pluripotent ES-like cells can differentiate into all three germ layers and organ lineages. Thus, spermatogonial stem cells have great potential for cell-based, autologous organ regeneration therapy for various diseases. We obtained testes from organ donors and using 1g pieces of tissue (biopsy size) we demonstrate that testis germ cells (putative spermatogonial stem cells and/or their progenitors) reprogram to pluripotecy when removed from their stem cell niche and when appropriate growth factors and reagents in embryonic stem cell medium are added. In addition, our method of obtaining pluripotent ES-like cells from germ cells is simpler than the described methods and may be more suitable if this procedure is developed for the clinic to obtain pluripotent cells to cure disease.
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005

  2. #2
    I'd give my left nut to walk again.

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