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Thread: Researchers cure mice with damaged spines using human iPS cells+

  1. #1
    Senior Member Duran's Avatar
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    Jul 2001
    Maximum security prison, Death row

    Researchers cure mice with damaged spines using human iPS cells+

    TOKYO, Feb. 4 (AP) - (Kyodo) - A research team at Keio University has succeeded in curing mice whose hind legs are paralyzed due to damage to the spinal cord by transplanting neural stem cells grown from human iPS cells, researchers reported Wednesday at a symposium held at the university in Tokyo.

    Hideyuki Okano, professor of physiology at the university and leader of the team, said it is the first case in the world in which the curative effects of human iPS cells, or induced pluripotent stem cells, have been confirmed.

    Currently, there is no effective treatment for spinal cord injuries that damage the nerves in the spine, often caused by traffic accidents and sports injuries, and treatment using iPS cell gives hope of a cure.

    Okano said, "It is valuable that treatment using human iPS cells has proved effective. We want to apply (the results) in a clinical setting as soon as possible."

    The research team generated neural stem cells, which will grow into nerve cells, from human iPS cells produced under a scheme that Shinya Yamanaka of Kyoto University developed.

    The team then transplanted some 500,000 neural stem cells into the damaged spines of 40 mice nine days after their injuries, which is believed to be the most effective time for transplant, according to Okano.

    The team used special kinds of mice that develop no immunological rejections in the transplants.

    About a month later, all 29 surviving mice had become able to walk or run. The other 11 mice died of diseases not related to the experiment.

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  2. #2
    In my opinion, this is a very important study. I know Okano and respect his work. Many laboratories are rushing now to assess the effects of IPS on various injury models. This may lead to clinical trials. Wise.

  3. #3

    regarding the news

    this is again an article about this case

    let's hope this evolves to human trials

  4. #4
    Senior Member Schmeky's Avatar
    Join Date
    Sep 2002
    West Monroe, LA, USA
    nine days after their injuries, which is believed to be the most effective time for transplant

  5. #5
    Quote Originally Posted by Schmeky View Post
    9 rat days = 36 human days = sub-acute, right?

    The implications to those of us on this board are no different, however.

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