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Thread: Transplanted Fat Cells Restore Function After Spinal Cord Injury

  1. #1
    Senior Member Max's Avatar
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    Transplanted Fat Cells Restore Function After Spinal Cord Injury

    Transplanted Fat Cells Restore Function After Spinal Cord Injury

    ScienceDaily (Dec. 10, 2008) — A new study suggests that mature adipocytes - fat cells - could become a source for cell replacement therapy to treat central nervous system disorders.

    According to the study's lead researcher, Dr. Yuki Ohta of the Institute of Medical Science, St. Mariana University School of Medicine, Kawasaki, Japan, adipose-derived stem/stromal cells have in the past been shown to differentiate into neuronal cells in an in vitro setting. In their study, for the first time fat cells have been shown to successfully differentiate into neuronal cells in in vivo tests. The fat cells are grown under culture conditions that result in them becoming de-differentiated fat (DFAT) cells.
    "These cells, called DFAT cells, are plentiful and can be easily obtained from adipose tissue without discomfort and represent autologous (same patient) tissue," said Ohta. "DFAT cells, with none of the features of adipocytes, do have the potential to differentiate into endothelial, neuronal or glial lineages."
    The research team reported that DFAT cells expressed neurotrophic factors, such as BDNF and GDNF, prior to and after transplantation and which likely contributed to the promotion of functional recovery.
    According to Ohta and colleagues, tests in animal models confirmed that the injected cells survived without the aid of immunosuppression drugs and that the DFAT-grafted animals showed significantly better motor function than controls.
    http://www.sciencedaily.com/releases...1210122254.htm

  2. #2
    Senior Member Max's Avatar
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    Fat cells restore spinal cord function after injury

    Fat cells restore spinal cord function after injury

    ISLAMABAD: Mature fat cells helped mice recover from spinal cord injuries, according to a promising new study.

    They could become a source for cell replacement therapy to treat central nervous system disorders in humans.
    Yuki Ohta of the St. Mariana University School of Medicine, Kawasaki, Japan, who led the study, said fat or adipose-derived stem cells have been shown to differentiate into neuronal cells in a test tube setting.
    Now, for the first time fat cells have been shown to successfully differentiate into neuronal cells in in-vivo (animal models) tests. The fat cells are grown under culture conditions that result in their becoming de-differentiated fat (DFAT) cells, according to a St Mariana release.
    "These cells, called DFAT cells, are plentiful and can be easily obtained from adipose tissue without discomfort and represent autologous (same patient) tissue," said Ohta.
    Tests in animal models confirmed that the injected cells survived without the aid of immunosuppression drugs and that the DFAT-grafted animals showed significantly better motor function than controls, said Ohta and colleagues.
    "We concluded that DFAT-derived neurotrophic factors contributed to promotion of functional recovery after spinal cord injury (SCI)," said Ohta. "Transplanting DFAT cells into SCI rats significantly promoted the recovery of their

    http://www.onlinenews.com.pk/details.php?id=137502

  3. #3
    Hmmm, I wonder what type of rats were used as some strains recover from mild SCI without treatment and the type oif injury they received since hemisection injuries aren't particularly difficult for rats to overcome.

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    Senior Member Scott Buxton's Avatar
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    I hope! Scott.

  5. #5
    Senior Member lurch's Avatar
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    I think I've got a few spare fat cells.

  6. #6
    Senior Member Schmeky's Avatar
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    Various cell types have been restoring documented levels of function since 1995 in the acute setting.

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