Int Arch Med. 2008 Sep 24;1(1):17.

Locally induced neural stem cells/pluripotent stem cells for in vivo cell replacement therapy.

Yuan TF, Arias-Carrión O.

Department of Anatomy, The University of Hong Kong, Li Kai Shing Faculty of Medicine, 21 Sassoon Road, Hong Kong, PR China.

ABSTRACT: Neural stem cells hold the key to innovative new treatments for age-associated degeneration and traumatic injury to the brain and spinal cord. We hypothesized that the in vivo induced pluripotent stem cells or neural stem cells through "forced gene expression" can be used to repair damaged brain areas or treat degenerative diseases. Hopefully, these in vivo patient-specific stem cells can bring a new avenue for cell replacement therapies.