Hi all, made an exciting discovery of a nutritional supplement that looks like it could help get rid of my spasticity from a high-level incomplete spinal cord injury. It's been very effective with people with MS, but my spasticity problem is similar to theirs and did respond well to 4-AP but nothing else. I've ordered Ca-AEP and will keep you informed of its effectiveness. Article below found in google search.



Membrane Integrity Factor Aids Multiple Sclerosis, Asthma and Osteoporosis
By Ward Dean, M.D. and Jim English
In 1941, a unique form of calcium, Calcium 2-amino ethyl phosphoric acid (Ca-AEP or Ca-2AEP) was discovered by the eminent biochemist Erwin
Chargaff. Chargaff found that Ca-AEP was a vital component in the structure of cell membranes. The significance of Chargaff’s work was largely ignored for the next two decades, but studies over the last 30 years have shown that Ca-AEP plays a vital role in maintaining cell membrane integrity and improving cellular functions. It has also been shown to be effective in supporting a host of conditions, including multiple sclerosis, diabetes, asthma and immune disorders.

A New Vitamin?

Ca-AEP
is one of a number of colamine phosphates—vitamin-like metabolites and cell membrane integrity factors, that are required for cellular membrane functions. Among these functions, Ca-AEP is known to acts as:


1) Cell Sealer and Protector

Cells allow entry of vital nutrients through pores spread across the cellular membrane. Two types of pores predominate: free lipid pores and peptide-lined transport pores. Lipidic pores can permit the unwanted penetration into cells by harmful agents. Ca-AEP decreases water solubility and seals the lipid cellular membrane pores, decreasing the permeability of the outer cell membrane by foreign substances. This action protects cells from invasion by toxins, bacteria, viruses, antibodies and other harmful agents.

2) Electrolyte and Nutrient Carrier

Ca-AEP facilitates the cellular exchange of inorganic electrolytes in cells and aids the absorption of nutrient substances such as fatty acids, amino acids, carbohydrates, vitamins, hormones and steroids through the ‘active transport pores’ of cell membranes.

3) Maintains Cell Electrical Charge

Ca-AEP maintains and repairs cellular neurotransmission, vital for the electrobiological connection of cells. Ca-AEP helps the cells to retain the electrical charges of calcium, potassium and magnesium ions residing on the membrane surface where they serve to increase the conductivity of nerve tissue. It does this by causing calcium and other minerals to bind to cellular membranes where they serve as electrical condensers, essential for cellular regulation.

This condenser function of the cell membrane plays an active role in disease prevention. If there is an insufficient amount of colamine phosphate salts, the cell’s electrical charge and condenser function will be abnormal. A significant loss of the electrical charge of the cell membrane may be catastrophic—especially for the circulatory system, immune system and neuromuscular system.

Diseases Involving Disturbance of Cell Membranes
Some illnesses are initiated when the body is unable to synthesize and incorporate into cell membranes adequate amounts of colamine phosphates such as Ca-AEP. Conversely, restoring levels of Ca-AEP to proper levels has been shown to improve membrane integrity and produce actions that are both therapeutic and preventive in nature. Among the diseases initiated or influenced by disturbances in cellular membranes are:



Multiple Sclerosis and sclerotic disorders, including Amyotrophic lateral sclerosis and progressive systemic sclerosis

Inflammatory disorders, including rheumatoid arthritis

Diabetes, both Insulin Dependent Diabetes Mellitus (IDDM) and Non-Insulin Dependent Diabetes Mellitus (NIDDM)

Diabetic complications, including diabetic nephropathy and retinopathy

Osteoporosis

Lung diseases, including asthma, emphysema and other conditions characterized by poor gaseous exchange in the alveoli

Immune disorders such as sarcoidosis


Multiple Sclerosis
The first trial applications of Ca-AEP were for the treatment of multiple sclerosis (MS). In 1967 the German Health Authority approved the use of Ca-AEP for MS. MS,
an inflammatory demyelinating condition, is one of the most common diseases of the central nervous system (brain and spinal cord). Myelin, the fatty material that surrounds nerves, acts as an insulator, much like the covering of an electric wire.

It is the speed and efficiency with which electrical impulses are conducted that permits smooth, rapid and coordinated movements to be performed with little conscious effort. In MS, the loss of the myelin sheath (demyelination) leads to a disruption in the ability of the nerves to conduct electrical impulses. It is believed that the loss of the ability of nerves to transmit impulses rapidly to and from the brain is what produces the various symptoms of MS.

The sites where myelin is lost (plaques or lesions) appear as hardened scars. In multiple sclerosis these scars appear at different times and in different areas of the brain and spinal cord — thus, the term Multiple Sclerosis literally means many scars.

An analysis of more than 2,000 patients who were treated with colamine salts in Germany over the course of 24 years revealed greater efficacy from Ca-AEP treatments than
other known treatments. In 1986, Dr. George Morrissette conducted a retrospective poll of patients in the USA who originally had begun Ca-AEP treatment in Germany for MS. 82% of the almost 300 patients that entered the study showed a positive benefit from Ca-AEP therapy. And when treatment began in the early stages of MS, positive results rose to 92%.

Additional Benefits
According to the work of Dr. Hans Nieper, MS should not be viewed as just a neurological disorder. MS is a generalized disease of the cellular membrane system that affects the nerves, bones, kidneys, lungs, red blood cells, blood vessels and many other organs and sites.

Long-term observation of Ca-AEP’s effects on more than 2,000 MS patients revealed a host of additional benefits. MS patients receiving Ca-AEP showed less signs of aging in their outward appearance, increased tissue elasticity and skeletal firmness and a marked absence of osteoporosis. Second to the destruction of the myelin sheath of the nerve fibers, MS patients are especially at risk of kidney infection due to insufficient membrane polarization at the cellular level.

While formerly one-third of all MS patients died due to lost nerve functions, one-third from increased tendency to bone fractures, and the last one-third from kidney failure, only two patients out of 2,200 treated with Ca-AEP suffered from these problems. Unusual bone fractures and problems with kidney functions were not observed at all.

The supplementation of Ca-AEP repairs cell membrane function and maintains it at optimal levels. It raises the depressed energy in the membrane system of the nerves’ myelin sheath of MS patients by several-fold, restoring proper synaptic function in the affected organs.

MS patients receiving Ca-AEP treatments have experienced facial and upper extremity mobility, body heat generation, greater relief from exhaustion and decreased spasticity.


............Much more to article. Notice that MS patients get decrease in spasticity.

Jan