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Thread: Frontiers in the surgical treatment of Parkinson's disease.

  1. #1

    Frontiers in the surgical treatment of Parkinson's disease.

    Expert Rev Neurother. 2008 Jun;8(6):897-906.

    Frontiers in the surgical treatment of Parkinson's disease.

    Remple MS, Sarpong Y, Neimat JS.

    Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

    Despite the continued refinement of medical and surgical therapies, the treatment of Parkinson's disease (PD) remains challenging. Current treatment strategies are largely focused on managing the motor symptoms of the disease, either by dopamine-based medications or, in advanced stages, by the application of deep brain stimulation to more stably alter the function of the basal ganglia. Important advances have been made in the last decade, but unfortunately a number of the motor symptoms of late-stage PD remain poorly treated, and while currently available therapies address the symptoms of the disease, they fail to alter the course of the disease itself. This has spurred basic and clinical exploration on a number of fronts. Several centers have examined novel stimulation targets to treat refractory symptoms of gait difficulty and axial imbalance. Basic and clinical researchers are examining whether the use of deep brain stimulation might slow the progress of the disease and thus be a useful neuroprotective therapy if initiated earlier in the progression of the disease. An expanded understanding of the genetic and cellular events that underlie PD has led some researchers to explore the use of neurotrophic factors or genetic restoration to preserve threatened neuronal populations. Finally, there has been much research on the use of fetal mesencephalic or stem cell populations to restore dopaminergic function. In this report, we will examine each of these potential new surgical therapies and the promise they may hold for the future treatment of PD.

    http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005

  2. #2
    good to see work is being done to help with late-stage symptoms and find new therapies.

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