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  1. Replies
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    Also, check this out at the End Paralysis...

    Also, check this out at the End Paralysis foundation website https://endparalysis.org/nih-disrupt...jury-research/
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    I suggest that you check out the "NIH Conference...

    I suggest that you check out the "NIH Conference on SCI Research" thread that lies just above mine. Take the survey that Skipow just posted (https://www.surveymonkey.com/r/SCI2020). Make your...
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    Just to be clear, our experiments were in adult...

    Just to be clear, our experiments were in adult rats, not mice. Even up to 1.5 years following the spinal cord injury, we began to see recovery in a little as 1 week following enzyme...
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    Thanks for the question. In our initial study...

    Thanks for the question. In our initial study we were attempting to target only the motor neurons that project out to the diaphragm. They are called "phrenic" motor neurons and they form a cigar...
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    Thanks for the question. We were not actually...

    Thanks for the question. We were not actually targeting the scar that surrounds the lesion, which was made at cervical level 2. We were targeting the so-called perineuronal net (PNN), a...
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    If you have any questions about our new work then...

    If you have any questions about our new work then please just ask and I will do my best to answer.

    Here is a link to the paper for all to read. it is open access. "Rapid and robust restoration...
  7. The focus of the company will be to move towards...

    The focus of the company will be to move towards human clinical trials. Large animal studies are already underway.
  8. Dear Lunasicc42, Lynnifer and others. I have...

    Dear Lunasicc42, Lynnifer and others. I have not posted in a very long time but I do read Care Cure on occasion. Thanks to Grammy and U2FP I see that you have learned about the founding of NervGen...
  9. The sequence of our peptide is published and can...

    The sequence of our peptide is published and can be purchased by anybody. It would , indeed, be interesting to learn if it can be used in a combinatorial strategy with a bioscaffold. In regards to...
  10. Dear JamesMcM, Yes, for sure this is a...

    Dear JamesMcM,

    Yes, for sure this is a difficult question that I am not able to answer. I know little about the rules that govern compassionate use. But let us first demonstrate a successful...
  11. We are using a T8 severe contusive injury and...

    We are using a T8 severe contusive injury and then allowing the animals to age 3 months before beginning treatment. We are using regular (Sigma) ch'ase +peptide, lenti-ch'ase + peptide as well as...
  12. The peptide is delivered systemically once per...

    The peptide is delivered systemically once per day either via sub-cutaneous or intra peritoneal injection. Experiments are now underway in chronically injured animals where we are combining ch'ase...
  13. Dear Comad, Thanks for your questions and your...

    Dear Comad,

    Thanks for your questions and your very kind personal comment. I am keeping my fingers crossed about the dog trial
    and at the same time being cautiously optimistic. I believe the...
  14. Edema occurs after injury as fluids exit the...

    Edema occurs after injury as fluids exit the vasculature into the astrocyte end feet that closely abut all the vessels in the CNS. The astrocytes swell as they fill with water. There is a special...
  15. The molecular components of glial scarring begin...

    The molecular components of glial scarring begin to form almost immediately after injury. The inhibitory proteoglycans of the scar are stimulated as soon as the blood brain barrier is broken. One...
  16. At acute stages following contusive SCI the...

    At acute stages following contusive SCI the peptide by itself is remarkable (Nature Lang et al, 2015). However, so far and at low doses the peptide has not been successful as a stand alone treatment...
  17. Right, I understand your frustration. I am...

    Right, I understand your frustration. I am frustrated too. If it were solely up to me we would, indeed, be in the clinic tomorrow, especially with our new results in a super chronic model. We will...
  18. Their model involves the production of trails...

    Their model involves the production of trails that might be used to guide axons over lengthy distances. Whether this strategy will work or not could be a topic for discussion elsewhere. Our model...
  19. ANSWER: we will be submitting to a major journal...

    ANSWER: we will be submitting to a major journal in the next few weeks.
  20. There are substantial differences in what we are...

    There are substantial differences in what we are attempting to do. The Iowa state strategy involves a heat stable chondroitinase whose residence time within the cord is perhaps a few weeks. Once the...
  21. Our strategy is relatively straightforward and...

    Our strategy is relatively straightforward and easy to administer. It is minimally invasive so theoretically anybody could do this.
  22. OK let me have a go at these but it is difficult...

    OK let me have a go at these but it is difficult to pinpoint an exact timeframe.

    The major reason that chondroitinase has not gone to clinical trials is because there has not been compelling...
  23. No problem of doing these experiments in the US. ...

    No problem of doing these experiments in the US. We just need the cooperation of a university with a good primate facility.
  24. The enzyme is administered through micro-needles...

    The enzyme is administered through micro-needles but the number of injections per area that would adequately cover the cord still needs to be worked out in a larger animal model. In our rat model we...
  25. Yes, for certain, incomplete chronic injuries are...

    Yes, for certain, incomplete chronic injuries are far more likely to respond best to the enzyme. As for money raising it is always appropriate for the SCI community to help call attention to and...
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