Originally Posted by

**thehipcrip**
I'm not really surprised that the overall increase of 50 didn't help as much as the bolus dose did. Increasing your dose of 50 ucgs per 24 hour days ends up- with significantly less concentration of the baclofen in your CSF than having a boost of 50 ucgs delivered in a period of a few hours.

While I'm no expert, I would calculate that to get the same effectiveness you had from the bolus, you would need to increase your daily dose by another 190 or so ucgs from where you were when you got that bolus.

I arrived at that number by guesstimating that the bolus delivered about 10 extra units of baclofen every hour for five hours, for a total of 50 units. To get that same level of saturation all the time, you'd need to up the total dose of baclofen by 10 units every hour -- 10 ucgs X 24 hours, less the 50 unit increase you've already had = 190 to go. :-) Bear in mind that all this is PFA squared math (the numbers were Pulled From Air and if they work out, it will be Pretty F**king Amazing). Of course now that I've made this prediction, I would be ever so grateful if you'd let me know what dose you finally land at!

Since you can't really go up that amount in one shot safely, it's going to take several more tweaks for you to get to the level my PFA2 math predicts you need to be. Do you ever go for dose adjustments in between refills, assuming that you're not in need of refills every month?