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    UWE59, I did not develop 4-AP. A colleague of mine at NYU did early experiments with the drug in spinal cord injury and designed the clinical trials that showed its efficacy for multiple sclerosis. Not everybody with MS will respond the Ampyra. If you don't have any beneficial effects from the drug within 4 weeks, I would discontinue it. The doses of 4-AP given for MS and SCI may differ. People with MS are more sensitive to 4-AP. Also, please note that Ampyra is a sustained release formulation while my earlier posts were relating to immediate release. Wise.
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