wildwilly
05-06-2008, 05:31 AM
Arch Ophthalmol. 2008 Apr;126(4):566-70.
NMO Antibody-Positive Recurrent Optic Neuritis Without Clear Evidence of Transverse Myelitis.
Dinkin MJ, Cestari DM, Stein MC, Brass SD, Lessell S.
Department of Neurology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115. mdinkin@partners.org.
http://www.ncbi.nlm.nih.gov/pubmed/18413533?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVDocSum
When a laboratory test becomes available for a disorder previously diagnosed solely on clinical grounds, the spectrum of that disorder is apt to be expanded. With the discovery of a blood test (the NMO antibody) that has an estimated sensitivity of 76% and a specificity of 94%,1 Devic disease is proving to be such an example. Devic recurrent neuromyelitis optica was considered a demyelinating disease in which the cardinal features were a bilateral optic neuropathy and a cervical myelopathy without other clinical or magnetic resonance imaging (MRI) evidence of involvement elsewhere in the nervous system and with a poor prognosis for recovery. With the advent of the NMO-antibody test, the picture of the syndrome is expanding.2 We report on the cases of 3 women who suffered from recurrent optic neuritis (ON) in association with the NMO antibody but who never developed clear evidence of a transverse myelitis in approximately a decade of follow-up.
more: http://archopht.ama-assn.org/cgi/content/full/126/4/566
NMO Antibody-Positive Recurrent Optic Neuritis Without Clear Evidence of Transverse Myelitis.
Dinkin MJ, Cestari DM, Stein MC, Brass SD, Lessell S.
Department of Neurology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115. mdinkin@partners.org.
http://www.ncbi.nlm.nih.gov/pubmed/18413533?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVDocSum
When a laboratory test becomes available for a disorder previously diagnosed solely on clinical grounds, the spectrum of that disorder is apt to be expanded. With the discovery of a blood test (the NMO antibody) that has an estimated sensitivity of 76% and a specificity of 94%,1 Devic disease is proving to be such an example. Devic recurrent neuromyelitis optica was considered a demyelinating disease in which the cardinal features were a bilateral optic neuropathy and a cervical myelopathy without other clinical or magnetic resonance imaging (MRI) evidence of involvement elsewhere in the nervous system and with a poor prognosis for recovery. With the advent of the NMO-antibody test, the picture of the syndrome is expanding.2 We report on the cases of 3 women who suffered from recurrent optic neuritis (ON) in association with the NMO antibody but who never developed clear evidence of a transverse myelitis in approximately a decade of follow-up.
more: http://archopht.ama-assn.org/cgi/content/full/126/4/566