View Full Version : Spleen Cells May Prove Effective Target for Lupus Treatment

09-14-2006, 02:54 PM
Researchers discover the organ is origin of the disease in 'transgenic' mice

By Serena Gordon

HealthDay Reporter

THURSDAY, Sept. 14 (HealthDay News) -- Research done on mice specially bred to develop lupus has uncovered an area of the spleen that may give rise to the disease.
The area is called the marginal zone of the spleen and it appears that this is where B cells from the immune system go awry and turn into cells that attack the body's own tissues and organs, researchers say.

This current work gives rise to new possibilities for targeted therapies that are perhaps much milder and more effective than current therapies," said the study's lead author, Thomas Enzler, a visiting scholar, internist and immunologist at the University of California, San Diego. However, he was quick to add that it would be a long time before any such potential therapy could be available for humans.

Results of the study were published Thursday in the online edition of the journal Immunity.

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