Max
07-15-2002, 04:19 PM
Roseolovirus infections after stem cell transplantation
Virologie. Vol. 6, Issue 3, May - June 2002: 199-207, Reviews
Summary: The immunosuppressive treatment following stem cell (SC) transplantation favours reactivation and replication of the Roseoloviruses. The high prevalence of human herpesviruses 6 and 7 (HHV6 and HHV7) among the general population and the lack of diagnostic methods to identify clearly active infections complicate the understanding of the real pathogenicity of these viruses. Nevertheless, HHV6 infections are frequent in SC graft recipients, and are associated to pathologies including encephalitis, pneumonitis, fever, skin rash, delayed engrafment and marrow suppression. The incidence of HHV7 infections and their potential clinical manifestations are less characterised. Further studies are required to establish the real impact of these viruses in SC transplanted patients. With that aim, methods for the rapid detection and the quantification of HHV6 and HHV7 are essential.
Author(s): D. Boutolleau, A. Gautheret-Dejean Keywords: Human herpesvirus 6 et 7 - Stem cell transplantation - Active viral infection - Pathogenicity.
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© John Libbey Eurotext
Virologie. Vol. 6, Issue 3, May - June 2002: 199-207, Reviews
Summary: The immunosuppressive treatment following stem cell (SC) transplantation favours reactivation and replication of the Roseoloviruses. The high prevalence of human herpesviruses 6 and 7 (HHV6 and HHV7) among the general population and the lack of diagnostic methods to identify clearly active infections complicate the understanding of the real pathogenicity of these viruses. Nevertheless, HHV6 infections are frequent in SC graft recipients, and are associated to pathologies including encephalitis, pneumonitis, fever, skin rash, delayed engrafment and marrow suppression. The incidence of HHV7 infections and their potential clinical manifestations are less characterised. Further studies are required to establish the real impact of these viruses in SC transplanted patients. With that aim, methods for the rapid detection and the quantification of HHV6 and HHV7 are essential.
Author(s): D. Boutolleau, A. Gautheret-Dejean Keywords: Human herpesvirus 6 et 7 - Stem cell transplantation - Active viral infection - Pathogenicity.
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© John Libbey Eurotext