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Wise Young
02-25-2006, 10:41 PM
http://www.cancerfacts.com/Home_News.asp?NewsId=1974&CB=14&CancerTypeId=4

Functioning prostate grown from embryonic stem cells
Source: (cancerfacts.com)
Thursday, February 23, 2006

MELBOURNE – Feb. 23, 2006 – A group of women scientists have grown the world's first human prostate from embryonic stem cells. The "man-made" prostate represents a giant step towards understanding prostate disease, the researchers say.

The research led by Drs. Prue Cowin and Dr Renea Taylor both of the Monash Institute of Medical Research (MIMR), in Clayton, Australia, outside Melbourne, produced functioning prostate tissue that secretes hormones and prostate specific antigen, which will allow scientists to better understand the natural aging process and prostate disease development, including cancer.

The study published in the March edition of Nature Methods describes how human embryonic stem cells were developed into human prostate tissue equivalent to that found in a young man, in just 12 weeks.

"We need to study healthy prostate tissue from 15-25 year old men to track this process," said Taylor in a prepared statement. "Understandably, there is a lack of access to samples from men in this age group, so to have found a way we can have an ongoing supply of prostate tissue is a significant milestone. As nearly every man will experience a problem with their prostate, we're very excited about the impact our research will have."

Wise Young
02-28-2006, 03:42 AM
I just saw this comment in Slate:
http://www.slate.com/id/2137001/fr/rss/

Scientists grew human prostate glands in mice. They combined mouse prostate cells with human embryonic stem cells, cultivated the combined tissue in the lab, and implanted it in mice, where it grew into functional human prostates. Advertised benefit: We can study the course, treatment, and prevention of cancer in these prostates without giving a damn about the hosts, since they're just mice. (For Human Nature's update on implanting human brain cells in mice, click here. For President Bush's warning against "creating human-animal hybrids," click here.)

This is a human-mouse chimera. The mice produce human semen. it cannot be far from when the mice can ejaculate human sperm.

Wise.

Steven Edwards
03-03-2006, 07:51 PM
This is a human-mouse chimera. The mice produce human semen. it cannot be far from when the mice can ejaculate human sperm.

Wise. I think this is the kind of thing Bush had in mind when mentioning chimeras. Can a "regular" mouse egg be fertilized by human sperm? If so, what would the offspring be?

Lindox
03-03-2006, 08:37 PM
I think this is the kind of thing Bush had in mind when mentioning chimeras. Can a "regular" mouse egg be fertilized by human sperm? If so, what would the offspring be?

Donald Rumsfeld.

Raven
03-03-2006, 08:40 PM
Thank you Steven for posing this question. It crossed my mind but then I thought it might start a problem between members opinions.

Honestly this kind of scares the heck out of me.

Dr. Young, is there a possibility that we might have things such as those depicted in that movie "Dr. Moreau's Island" as a result?

Raven

Steven Edwards
03-03-2006, 09:04 PM
Thank you Steven for posing this question. It crossed my mind but then I thought it might start a problem between members opinions.

Honestly this kind of scares the heck out of me.

Dr. Young, is there a possibility that we might have things such as those depicted in that movie "Dr. Moreau's Island" as a result?

Raven Raven, please never censor yourself from asking a legitimate question. Discussion is a good thing.

I think diploid mice cells only have 40 chromosomes (reference (http://faculty.virginia.edu/mammgenetics/chromosomes.html); (19+1)*2), so I doubt regular and chimeric mice could breed. But, I may be wrong, thus my question. :)

Lindox, heh. :D

Raven
03-04-2006, 10:20 PM
While reading Lindy's response, which I thought was so funny, another thought crossed my mind. Would this type of experiment be used on other animals later on or is it already being done but kept quiet?

Something else, just how much of a chance of mixing of animal and human be possible so that there might be some type of "new species"? All kinds of thoughts, questions and possibilities cross my mind with this article and as I stated before, it scares me.

Raven

Raven
03-06-2006, 11:22 PM
Bumping this up for reply from Wise.

Trevor
03-07-2006, 12:52 AM
I think this is the kind of thing Bush had in mind when mentioning chimeras. Can a "regular" mouse egg be fertilized by human sperm? If so, what would the offspring be?

Heres a few pics of what it would be.

Wise Young
03-07-2006, 07:46 AM
Donald Rumsfeld.

Lindox, you are getting wicked. The poor man.

From an evolutionary perspective, a chimeric union would be an efficient way to promote survival of genes. The day cannot be far off that we would simply have animals that carry our eggs and our sperms. They can the "dirty" stuff. Technicians in white coats harvest the embryo and implant it (into a synthetic uterus). Voila. Painless and pleasureless procreation. No angst or risk. As many as you would like and forever if necessary.

Wise.