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02-05-2006, 02:27 PM
Ann Neurol. (javascript:AL_get(this, 'jour', 'Ann Neurol.');) 2006 Feb 1; [Epub ahead of print]Related Articles, (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Display&dopt=pubmed_pubmed&from_uid=16453327&tool=ExternalSearch) Links (javascript:PopUpMenu2_Set(Menu16453327);) http://www.ncbi.nlm.nih.gov/entrez/query/egifs/http:--www3.interscience.wiley.com-images-wiley_interscience_134x30.gif (http://www.ncbi.nlm.nih.gov/entrez/utils/lofref.fcgi?PrId=3058&uid=16453327&db=pubmed&url=http://dx.doi.org/10.1002/ana.20770)
Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis.
Weinshenker BG (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Weinshenker+BG%22%5BAuthor%5D), Wingerchuk DM (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Wingerchuk+DM%22%5BAuthor%5D), Vukusic S (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Vukusic+S%22%5BAuthor%5D), Linbo L (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Linbo+L%22%5BAuthor%5D), Pittock SJ (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Pittock+SJ%22%5BAuthor%5D), Lucchinetti CF (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Lucchinetti+CF%22%5BAuthor%5D), Lennon VA (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Lennon+VA%22%5BAuthor%5D).
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN.
OBJECTIVE: We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis. METHODS: Prospective study of patients with initial LETM who were tested for the presence of NMO-IgG. RESULTS: Eleven of 29 patients (37.9%) were seropositive after a first attack of LETM spanning three or more vertebral segments on magnetic resonance imaging. Of 23 patients followed up for 1 year, none of 14 who were seronegative experienced a relapse or developed optic neuritis. Of 9 seropositive patients, 5 developed a second event: 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis (p = 0.004). INTERPRETATION: LETM represents an inaugural or limited form of NMO in a high proportion of patients. The 40% of patients who are seropositive for NMO-IgG are at high risk for relapse. Ann Neurol 2006.
PMID: 16453327 [PubMed - as supplied by publisher]
Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis.
Weinshenker BG (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Weinshenker+BG%22%5BAuthor%5D), Wingerchuk DM (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Wingerchuk+DM%22%5BAuthor%5D), Vukusic S (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Vukusic+S%22%5BAuthor%5D), Linbo L (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Linbo+L%22%5BAuthor%5D), Pittock SJ (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Pittock+SJ%22%5BAuthor%5D), Lucchinetti CF (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Lucchinetti+CF%22%5BAuthor%5D), Lennon VA (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Lennon+VA%22%5BAuthor%5D).
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN.
OBJECTIVE: We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis. METHODS: Prospective study of patients with initial LETM who were tested for the presence of NMO-IgG. RESULTS: Eleven of 29 patients (37.9%) were seropositive after a first attack of LETM spanning three or more vertebral segments on magnetic resonance imaging. Of 23 patients followed up for 1 year, none of 14 who were seronegative experienced a relapse or developed optic neuritis. Of 9 seropositive patients, 5 developed a second event: 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis (p = 0.004). INTERPRETATION: LETM represents an inaugural or limited form of NMO in a high proportion of patients. The 40% of patients who are seropositive for NMO-IgG are at high risk for relapse. Ann Neurol 2006.
PMID: 16453327 [PubMed - as supplied by publisher]