roshni
11-28-2005, 04:51 PM
"The Neurobiology of Spinal Cord Injury"
edited by Robert G. Kalb and Stephen M. Strittmatter?
Neurobiology of Spinal Cord Injury
ANNOTATION
The book contains predominantly black-and-white illustrations, with some color illustrations. This book highlights the major areas of basic science research in which progress is currently being made in the battle against the problem of spinal cord injury (SCI). It presents important advances in developing effective intervention to promote functional recovery after spinal cord injury through studies on animal models. A number of important insights on human injured spinal cords are presented through an experimentally induced lesion model system. A particularly exciting set of experiments provides compelling evidence for spinal learning — the ability of the isolated cord to make adaptations to new environmental demands. Specific problems are discussed including keeping the maximal number of neurons and glial cells alive after injury, promoting the extension of axons past the lesion site, and promoting myelination of surviving axons. This book delineates the major areas in which therapeutic interventions may alleviate the neurological deficit of spinally injured patients, and this research bodes well for the prospect of clinically successful interventions to achieve restoration of neurological performance in humans.
SYNOPSIS
Neurobiology of Spinal Cord Injury highlights the major areas of basic science research in which progress is currently being made in the battle against the problem of spinal cord injury (SCI). It presents important advances in developing effective intervention to promote functional recovery after spinal cord injury through studies on animal models. A number of important insights on human injured spinal cords are presented through an experimentally induced lesion model system. A particularly exciting set of experiments provides compelling evidence for spinal learning-the ability of the isolated cord to make adaptations to new environmental demands. Specific problems are discussed including keeping the maximal number of neurons and glial cells alive after injury, promoting the extension of axons past the lesion site, and promoting myelination of surviving axons. This book delineates the major areas in which therapeutic interventions may alleviate the neurological deficit of spinally injured patients, and this research bodes well for the prospect of clinically successful interventions to achieve restoration of neurological performance in humans.
FROM THE CRITICS
Booknews
Researchers and physicians review the latest scientific information concerning spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. Topics addressed include the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Treatments addressed include cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Of likely use to neuroscientists, neurologists, neurochemists, and scientists and physicians specializing in spinal cord injury. Annotation c. Book News, Inc., Portland, OR (booknews.com)
ACCREDITATION
Kalb, Robert G., MD (Yale Univ); Strittmatter, Stephen M., MD, PhD (Yale Univ)
edited by Robert G. Kalb and Stephen M. Strittmatter?
Neurobiology of Spinal Cord Injury
ANNOTATION
The book contains predominantly black-and-white illustrations, with some color illustrations. This book highlights the major areas of basic science research in which progress is currently being made in the battle against the problem of spinal cord injury (SCI). It presents important advances in developing effective intervention to promote functional recovery after spinal cord injury through studies on animal models. A number of important insights on human injured spinal cords are presented through an experimentally induced lesion model system. A particularly exciting set of experiments provides compelling evidence for spinal learning — the ability of the isolated cord to make adaptations to new environmental demands. Specific problems are discussed including keeping the maximal number of neurons and glial cells alive after injury, promoting the extension of axons past the lesion site, and promoting myelination of surviving axons. This book delineates the major areas in which therapeutic interventions may alleviate the neurological deficit of spinally injured patients, and this research bodes well for the prospect of clinically successful interventions to achieve restoration of neurological performance in humans.
SYNOPSIS
Neurobiology of Spinal Cord Injury highlights the major areas of basic science research in which progress is currently being made in the battle against the problem of spinal cord injury (SCI). It presents important advances in developing effective intervention to promote functional recovery after spinal cord injury through studies on animal models. A number of important insights on human injured spinal cords are presented through an experimentally induced lesion model system. A particularly exciting set of experiments provides compelling evidence for spinal learning-the ability of the isolated cord to make adaptations to new environmental demands. Specific problems are discussed including keeping the maximal number of neurons and glial cells alive after injury, promoting the extension of axons past the lesion site, and promoting myelination of surviving axons. This book delineates the major areas in which therapeutic interventions may alleviate the neurological deficit of spinally injured patients, and this research bodes well for the prospect of clinically successful interventions to achieve restoration of neurological performance in humans.
FROM THE CRITICS
Booknews
Researchers and physicians review the latest scientific information concerning spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. Topics addressed include the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Treatments addressed include cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Of likely use to neuroscientists, neurologists, neurochemists, and scientists and physicians specializing in spinal cord injury. Annotation c. Book News, Inc., Portland, OR (booknews.com)
ACCREDITATION
Kalb, Robert G., MD (Yale Univ); Strittmatter, Stephen M., MD, PhD (Yale Univ)